What is Erwinia used for?
Asparaginase erwinia chrysanthemi is used with other chemotherapy medications to treat acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells).
Why is asparaginase used in the treatment of leukemia?
Asparaginase is used to treat acute lymphocytic leukemia (ALL). It works by starving tumor cells of needed nutrients and slowing tumor cell growth.
What is the mechanism of action of asparaginase?
Chemistry and Mechanism of Action: Asparaginase hydrolyzes serum asparagine to nonfunctional aspartic acid and ammonia, depriving tumor cells of a required amino acid; thus, tumor cell proliferation is blocked by the interruption of asparagine-dependent protein synthesis.
Is asparaginase chemotherapy?
Drug type: L-asparaginase is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “enzyme.” (For more detail, see “How this drug works” section below).
How is Erwinia treated?
There are no compounds that can rid infected plants of Erwinia; although, bactericides containing copper can help slow the spread of the pathogen. Antibiotics have been recommended, but the bacteria adapt and populations become resistant within a matter of weeks.
How much does asparaginase cost?
The mean total drug costs for Erwinia asparaginase were $126,831, which corresponds with 149 vials of Erwinia asparaginase. The costs of the drug asparaginase itself accounted for 44.1%, 74.5%, and 19.2% of the total treatment costs of the intensification phase for the three groups, respectively.
What are 2 primary uses for asparaginase?
Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL). It is given by injection into a vein, muscle, or under the skin….Asparaginase.
| Clinical data | |
|---|---|
| IUPHAR/BPS | 7347 |
| DrugBank | DB00023 |
| ChemSpider | none |
| UNII | G4FQ3CKY5R |
Why is asparaginase important?
L-asparaginase is one of the most important agent used in multidrug chemotherapy regimens in the treatment of malignancies which derive from lymphoid system (acute lymhoblastic leukemias and non-hodgkin lymphoma).
Who makes Erwinia?
Spectrila is a recombinant E. coli asparaginase. Asparaginase produced by Dickeya dadantii (formerly called Erwinia chrysanthemi) instead is known as crisantaspase (BAN), and is available in the United Kingdom under the brand name Erwinase. One of the E.
What type of drug is Asparaginase?
Enzyme
Asparaginase/Classification
Drug type: Asparaginase is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “enzyme.” (For more detail, see “How this drug works” section below).
How do you control Xanthomonas?
There are no bactericides to combat the pathogen. Preventive cultural methods such as proper sanitation and watering practices are the best way to control Xanthomonas leaf spot.