What drugs cause lichenoid drug eruption?
Medications commonly reported to trigger a lichenoid drug eruption include:
- Antihypertensives – ACE inhibitors, beta-blockers, nifedipine, methyldopa.
- Diuretics – hydrochlorothiazide, frusemide, spironolactone.
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Phenothiazine derivatives.
Is simvastatin associated with oral lichenoid drug reaction?
Simvastatin and oral lichenoid drug reaction Roger et al. 5 first reported the side effects of simvastatin in 1994, describing that it induced lichenoid drug eruption on the skin and oral mucosa. The diagnosis of oral lichenoid drug reaction (OLDR) is sometimes very difficult when a patient takes multiple medications.
Which is the most common drug associated with lichenoid like eruptions?
A lichenoid drug eruption is a reaction to a medication. Some of the types of drugs that may trigger this condition include: anticonvulsants, such as carbamazepine (Tegretol) or phenytoin (Dilantin, Phenytek) antihypertensives, including ACE inhibitors, beta-blockers, methyldopa, and nifedipine (Procardia)
Can simvastatin cause skin rash?
Statins have also been associated with a number of cutaneous conditions (e.g. eczematous skin rash, cutaneous lupus erythematosus, porphyria cutanea tarda, bullous dermatosis, UV-B phototoxicity, acute generalized exanthematous pustulosis, cheilitis, photosensitivity and dermatomyositis-like syndrome).
What causes a lichenoid reaction?
Lichenoid reaction (LR) is an adverse effect which may be caused by systemic administration of drugs including antihistamine, corticosteroid and some other triggers. The prevalence of LR has been reported to be approximately 2.4% in the general population and occurs in women three times more than in men.
What causes lichenoid?
Lichenoid keratosis is an inflammatory reaction arising in a regressing existing solar lentigo or seborrhoeic keratosis. It is not known what causes the reaction, but triggers can include minor trauma such as friction, drugs, dermatitis, and sun exposure.
Can simvastatin cause lichen planus?
Cholesterol-lowering statins, commonly used in the management of cardiovascular disease, provoke skin complaints such as xerosis and itch, lichen planus pemphigoides, eczema, and dermatomyositis in approxima tely 5% of patients receiving therapy.
What is Lichenoid drug eruption?
INTRODUCTION. Lichenoid drug eruption, also called drug-induced lichen planus, is an uncommon cutaneous adverse effect of several drugs [1-4]. It is characterized by a symmetric eruption of flat-topped, erythematous or violaceous papules resembling lichen planus on the trunk and extremities.
How is lichenoid eruption treated?
The first choice for treatment of lichen planus is usually a prescription corticosteroid cream or ointment. If that doesn’t help and your condition is severe or widespread, your doctor might suggest a corticosteroid pill or injection.
What causes lichenoid inflammation?
The exact cause of lichenoid keratosis isn’t known. It may be due to an inflammatory reaction. This happens when your immune system mistakenly attacks the skin. This reaction may be triggered by excess sun or UV light exposure, skin irritation, and some medications.
Can statins cause skin issues?
Statins can make your skin more porous, allowing more water to escape, which in turn dries your skin. In some severe cases, statins have been known to cause a dry skin rash and flaky skin that mimics eczema.
What are simvastatin side effects?
Simvastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- constipation.
- stomach pain.
- nausea.
- headache.
- memory loss or forgetfulness.
- confusion.
- itchy or red skin.