What are NCr mice?
Athymic Nude mouse, Crl:NU(NCr)-Foxn1nu Athymic Nude mice are used in oncology, especially in the study of tumors biology and also in transplantology and immunological research.
What strain of mice are athymic?
Nude mice
Nude mice are also athymic; homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. Homozygous nude mice show partial defect in B cell development.
What is athymic mouse?
A type of laboratory mouse that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation. Athymic nude mice are often used in cancer research because they do not reject tumor cells, from mice or other species.
How are nude mice produced?
A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the “nude” nickname.
What is NOD SCID mice?
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD. NSG branded mice are among the most immunodeficient described to date. NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells.
Why do nude mice not have hair?
The cuticles of the inner root sheath and the hair are not built up, the cortex of the hair being composed by abnormal globular aggregates. These results demonstrate that athymic, nude mice are not hairless but that the development and differentiation of hairs are severely injured in this mouse mutant.
Why are nude mice immunocompromised?
Nude mouse models contain a genetic mutation that causes the thymus to be absent or deteriorated. This mutation results in a suppressed immune system due to the reduced number of T cells.
What is the meaning of athymic?
Athymic: Lacking a thymus gland.
Why do scientists use nude mice?
Caused by a genetic mutation, nude mouse models lack a normal immune system and thymus gland. They have a repressed immune system due to reduced number of T cells. Nude mice are ideal for tumor and tissue studies because they have no rejection responses and are hairless, making it easier to identify tumors.
Why are nude mice bald?
Nude mice, in their various forms, contain a genetic mutation that results in the lack of a thymus and therefore a significantly inhibited immune system3. The genetic mutation is an inactivating mutation in the FOXN1 gene. In 1994, it was shown that this mutation is the cause of the lack of visible hair in nude mice4.
What are SCID beige mice?
SCID-bg (scid/scid, beige/beige) is a strain of double-mutant mice with impaired lymphoid development and reduced natural killer (NK) cell activity. The present study was undertaken to evaluate the usefulness of SCID-bg mice as xenograft recipients.
What kind of mice are used in NCR studies?
NCr Nude Mice | Athymic Mouse Model | Taconic Biosciences NCr nude mice are the standard athymic model for National Cancer Institute (NCI) studies as well as many pharmaceutical and oncology screening programs. Toggle navigation
Are there any studies on the anaerobic threshold in mice?
Compared to the paucity of data measuring the anaerobic threshold in mice, a great number of studies focus on physical activity without measuring their exercise capacity and no regard for strain variation [ 16 ], making it difficult to compare data between research groups.
Why do homozygous mice have no fur?
The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues. Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair.
How is the reliability of lactate measured in mice?
Reproducibility of the lactate measurements was determined using test-retest measurements on 5–6 mice. The Pearson´s r between two succeeding lactate measurements at rest was 0.43, however this was significantly improved to 0.92 when the mice were acclimated daily for 3–4 days prior to the restraint and lactate measurement procedure (tail pinch).