What does CD138 negative mean?
Endometrial CD138 count appears to be a negative prognostic indicator for patients who have experienced previous embryo transfer failure – Fertility and Sterility.
Can plasma cells be CD138 negative?
CD138 negative plasma cells are a sub-population of malignant plasma cells (PCs) which may be more primitive and have a higher proliferative potential than CD138 positive plasma cells [1].
What is CD138 a marker for?
During normal B-cell development, cells acquire expression of CD138, also known as syndecan-1 (SDC1), a marker highly specific for terminally differentiated normal plasma cells (1). CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2).
What is CD38 and CD138?
Abstract. Background/Aim: CD38 is a cell surface marker commonly present in plasma cells and activated T cells, while CD138 is a representative plasma cell marker.
What does positive for CD138 mean?
CD138 is a classic plasma cell marker and can be found on both normal polyclonal or abnormal monoclonal plasma cells. Being CD138 positive and knowing the total plasma cell % from the core bone specimin would be the best markers to understand the extent of bone marrow infiltration.
What is a CD138 test?
CD138 is a protein present on plasma cells in the bone marrow, and on certain epithelial cells. The protein is useful to diagnose any neoplasms (tumors) growing in plasma cells. The test, called Immunohistochemistry, involves obtaining a tissue specimen from the patient, and staining it with the CD138 stain.
What does CD138 stain?
CD138 is expressed on plasma cells and can be useful in the diagnosis of plasma cell neoplasms. Epithelial cells and endothelial cells may also express CD138. In normal tonsil tissue, CD138 strongly stains the membranes of mature plasma cells and squamous epithelial cells.
What does CD138 positive plasma cells mean?
Do T cells express CD138?
Similar to C3H gld mice, a large population of CD138-expressing T cells accumulate in peripheral organs of Fas receptor mutant μMT/Lpr, B6/Lpr (25) and MRL/Lpr mice (Figure 1A). As previously described, the majority of CD138+ T cells also express CD3 and B220 and are negative for CD4 and CD8 (dnT).
What is the role of CD138 in immunohistochemistry?
The PCs can be counted manually on the CD138-immunostained sections and correlate well with the counts obtained by image analysis. The use of CD138 along with the light chain and CD56 IHC adds a high diagnostic value in myeloma patients and suspected myeloma cases.
What is the role of CD138 and light chain?
CD56 expression was significantly higher in patients with lytic lesions (78.26% vs. 21.74%). CD138, anti-κ, and anti-λ IHC also helped classify 11/19 (57.8%) cases correctly. Conclusion: The use of CD138 along with the light chain and CD56 IHC adds a high diagnostic value in myeloma patients and suspected myeloma cases.
What is the role of CD56 in plasma cell myeloma?
CD56 expression was seen in ~62.85% diagnosed myeloma cases while it was negative in cases of reactive plasmacytosis. CD56 expression was significantly higher in patients with lytic lesions (78.26% vs. 21.74%). CD138, anti-κ, and anti-λ IHC also helped classify 11/19 (57.8%) cases correctly.
How many myelomas were diagnosed with CD138 IHC?
The study comprised 35 diagnosed myelomas, 20 reactive plasmacytosis, and 19 M-band positive suspected myelomas. CD138 IHC was performed on all cases along with CD56, anti-κ, and anti-λ IHC. PCs were counted on CD138-immunostained sections by manual count and by image analysis.