Can duloxetine be dissolved in water?
The water solubility of duloxetine hydrochloride was determined to be 21.6, 2.74, and 0.331 g/L at pH 4, 7, and 9, respectively (Study 1982.6114).
Is duloxetine HCL the same as Cymbalta?
Also, your risk for certain side effects may be higher when you first start taking the drug. For example: Your risk for suicidal thoughts or behaviors may be highest in your first few months of taking Cymbalta or after your dose is changed. However, this can occur at any time while taking Cymbalta.
Is duloxetine an acid or a base?
Absorption: Duloxetine is acid labile, and is formulated with enteric coating to prevent degradation in the stomach. Duloxetine has good oral bioavailability, averaging 50% after one 60 mg dose.
What is duloxetine chemical structure?
C18H19NOS (Duloxetin)
Duloxetine/Formula
Why is duloxetine enteric coated?
Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 20, 30, or 60 mg of duloxetine, respectively. These enteric-coated pellets are designed to prevent degradation of the drug in the acidic environment of the stomach.
Can you sprinkle Cymbalta on food?
Do not open the Cymbalta® delayed-release capsule and sprinkle the contents on food or in liquids. If you cannot swallow the Drizalma Sprinkle™ delayed-release capsule whole, you may do the following: You may open the capsule and sprinkle the contents over one tablespoon (15 mL) of applesauce.
How long does it take for duloxetine HCL to work?
Duloxetine normally takes 2 to 4 weeks to work. It may take longer if you’re taking it for nerve pain. Common side effects include feeling sick, a dry mouth, headache, constipation and feeling sleepy. These side effects are usually mild and go away after a couple of weeks.
What does duloxetine HCL do?
Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).
Is duloxetine an antagonist?
MK-869 is a substance P neurokinin-1 receptor antagonist. These agents are corticotropin releasing hormone receptor-1 antagonist. Duloxetine inhibits the reuptake of both serotonin and norepinephrine.
How big is the Ki of duloxetine hydrochloride?
Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). MedChem Express
Which is the hydrochloride salt of duloxetine?
Duloxetine Hydrochloride is the hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity.
What are the side effects of taking duloxetine?
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It is taken by mouth. Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating.
How long is the half life of duloxetine?
Duloxetine has an elimination half-life of about 12 hours (range 8 to 17 hours) and its pharmacokinetics are dose proportional over the therapeutic range. Steady-state plasma concentrations are typically achieved after 3 days of dosing.