What does protein S deficiency cause?
Protein S deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots. Individuals with mild protein S deficiency are at risk of a type of clot called a deep vein thrombosis (DVT) that occurs in the deep veins of the arms or legs.
What level is considered protein S deficiency?
In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were <2.5th percentile of the controls.
Can protein S fluctuate?
Reliable estimates for the prevalence of protein S deficiency in the general population are not available and the risk of thrombosis is a controversial issue. It has been shown that levels of protein S fluctuate over time. However the determinants of low levels of protein S in the healthy population are not clear.
Can protein S deficiency reversed?
Antithrombin deficiency may also be acquired; in such cases, the disorder may be reversible with resolution/improvement in the disease process responsible for the deficiency.
How do you fix protein S deficiency?
There is not a specific therapy for patients with protein S deficiency. The use of anticoagulant therapy however is highly effective in the treatment and prevention of blood clots in patients with the common type of protein S deficiency (due to inheritance of one abnormal protein S gene).
Can you have a baby with protein S deficiency?
Protein S deficiency is a rare inherited thrombophilia often associated with fetal losses in pregnancy. It is seen in approximately 1 in 500 to 1 in 3,000 people. Homozygous Protein S deficiency in neonates manifests as a catastrophic and fatal thrombotic complication termed Purpura Fulminans (PF).
When to seek treatment for protein’s deficiency?
Treatment of protein S deficiency occurs either in patients who have had a venous thrombosis or in patients with asymptomatic carrier states without a thrombotic event, depending on the decisions made by the patient’s health care provider.
Can a protein’s deficiency be a genetic disease?
Rarely, protein S deficiency is acquired, meaning it develops as a result of another condition such as liver disease, kidney disease or vitamin K deficiency. [3] Do you have updated information on this disease? We want to hear from you. Making a diagnosis for a genetic or rare disease can often be challenging.
What are the side effects of protein deficiency?
The two most common findings associated with protein S deficiency are deep vein thrombosis and pulmonary embolism. Deep vein thrombosis or DVT is a clot that forms in the legs. This can be painful and can cause the leg to swell, but the clots can form without pain or swelling too.
How are blood clots treated with protein’s deficiency?
Standard Therapies There is not a specific therapy for patients with protein S deficiency. The use of anticoagulant therapy however is highly effective in the treatment and prevention of blood clots in patients with the common type of protein S deficiency (due to inheritance of one abnormal protein S gene).