What is the mechanism of action of nikethamide?
Nikethamide increases the development of tension of a muscle stimulated indirectly at low frequencies (fig. 2A and 2B) and produces a depression of muscular contraction when the stimuli are of higher frequencies (fig. 1 and 2C). Nikethamide depresses the first stage of neuromuscular transmission (fig.
What are respiratory stimulants?
Respiratory stimulants such as aminophylline and caffeine have been shown to be effective to increase respiratory center activity in preterm infants and to decrease the incidence of severe apneic episodes.
Which drug is used as Analeptic?
Amphetamine, methamphetamine, and dextroamphetamine are powerful analeptics that are used because of their psychostimulant and appetite depressant effects.
What is the chemical formula of coramine?
C10H14N2O
Nikethamide/Formula
What is Picrotoxin used for?
Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
What is the most powerful respiratory stimulant?
Carbon dioxide is one of the most powerful stimulants of breathing. As the partial pressure of carbon dioxide in arterial blood rises, ventilation increases nearly linearly.
What is coramine in chemistry?
Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion.
What is an analeptic drug examples?
Analeptic Agent
- Methamphetamine.
- Protein.
- Metabolite.
- Alkaloid.
- Cocaine.
- (-)-Ephedrine.
- Caffeine.
- Amphetamine.
Is Buspirone a respiratory stimulant?
Buspirone, a nonbenzodiazepine anxiolytic agent, has little reported sedative effect. It has been shown to be a respiratory stimulant in an anesthetized, glomectomized cat model.
What is the use of Solapsone?
Solasulfone is a sulfonamide antibiotic used in the treatment of leprosy.
What is Glutethimide used for?
Glutethimide is a hypnotic and sedative agent intended to treat insomnia. The hypnotic effect is roughly analogous to that of pentobarbital. It is given to patients who cannot tolerate barbiturates.
What does muscimol do to your brain?
Muscimol is a potent GABAA agonist, activating the receptor for the brain’s principal inhibitory neurotransmitter, GABA. GABAA receptors are widely distributed in the brain, and so when muscimol is administered, it alters neuronal activity in multiple regions including the cerebral cortex, hippocampus, and cerebellum.