What is the source of 2 4-dinitrophenol?
nitro groups
A dinitrophenol having the nitro groups at the 2- and 4-positions….CHEBI:42017.
| Synonyms | Sources |
|---|---|
| 2,4-DINITROPHENOL | PDBeChem |
| 2,4-DNP | NIST Chemistry WebBook |
| α-dinitrophenol | NIST Chemistry WebBook |
What is DNP in electron transport?
DNP gradually inhibits electron transport itself as it is incorporated into mitochondrial membranes. The effects appear to depend on concentration of DNP and of mitochondria, and vary from one preparation to the next.
What is the mechanism of action of 2 4 DNP?
2,4-Dinitrophenol elevates the BMR, lowers the serum T4 concentration, accelerates the peripheral metabolism of T4, and depresses thyroidal RAIU and secretion. Its actions are probably complex. Like T4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria.
Does dinitrophenol increase oxygen consumption?
IT has long been recognized that 2,4-dinitrophenol increases oxidative metabolism. The increase of oxygen consumption after the addition of 2,4-dinitrophenol (DNP) is explained as being a result of dissociation between oxidative and phosphorylative processes.
How does 2/4 dinitrophenol affect cellular respiration?
Mitochondrial uncouplers, such as 2,4 dinitrophenol (DNP), increase the cellular respiration by decreasing mitochondrial membrane potential (delta psi). Moreover the decrease in ATP/ADP ratio induced by DNP is partially restored by addition of octanoate or proline.
What is the effect of 2/4 dinitrophenol on mitochondria?
DNP acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat.
How does 2/4 dinitrophenol prevent ATP synthesis in mitochondria?
DNP acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient.
How does 2/4-dinitrophenol prevent ATP synthesis in mitochondria?
Is 2/4-dinitrophenol an acid or base?
2,4-dinitrophenol is a dinitrophenol having the nitro groups at the 2- and 4-positions. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite, an antiseptic drug, an allergen and a geroprotector. It is a conjugate acid of a 2,4-dinitrophenol(1-).
Why is 2/4 dinitrophenol stronger than O nitrophenol?
(ii) O-amino phenol and m-amino phenol. (i) 2, 4, 6 trinitro phenol (picric acid) is stronger acid than 2, 4-dinitrophenol as it contains three electron withdrawing NO2 groups. Hence, m-amino phenol is more acidic than o-amino phenol.
Is 2 nitrophenol a strongest acid?
The nitro group (−NO2) and (−Cl) both are the electron withdrawing groups which means it withdraws electrons from the electro centre. Both substituents are electron withdrawing groups but nitrophenol is more acidic than chlorophenol due to resonance.
Why is nitrophenol so acidic?
This is typically due to an electronegativity difference between the atoms at either end of the bond. Thus, ortho and para-nitrophenols are more acidic than m-nitrophenol is a little less acidic than p-nitrophenol because of intramolecular hydrogen bonding which makes the loss of a proton difficult to remove.
What are the side effects of 2, 4-dinitrophenol?
2,4-Dinitrophenol is used in the manufacture of dyes, wood preservatives, and as a pesticide. The acute (short-term) effects of 2,4-dinitrophenol in humans through oral exposure are nausea, vomiting, sweating, dizziness, headaches, and loss of weight.
When was 2, 4-dinitrophenol used as a diet pill?
2,4-Dinitrophenol is used in the manufacture of dyes and wood preservatives, as a pesticide, and as an indicator for the detection of potassium and ammonium ions. (1,6) During the 1930s, 2,4-dinitrophenol was used as a diet pill, but this use was stopped in 1938. (1) Sources and Potential Exposure
What is the detection limit for 2, 4-dinitrophenol?
Under the prescribed conditions, for 2,4-dinitrophenol the method detection limit is 13.0 ug/l using flame ionization detection and 36.0 ug/l using electron capture detection. Precision and method accuracy were found to be directly related to analyte concentration and essentially independent of the sample matrix.