What organisms do carbapenems cover?
Carbapenems also have good activity against most Gram-negative bacteria, including Enterobacter, E. coli, Morganella morganii, and Klebsiella. For the very resistant P. aeruginosa, doripenem and meropenem are highly potent because they require multiple drug resistance pathways.
What drug belongs to the group of carbapenems?
The carbapenem antibiotics imipenem, meropenem, ertapenem, and doripenem have a broad antimicrobial spectrum,199 with activity against almost all aerobic and anaerobic pathogens, although Enterococcus faecium are resistant.
What coverage does meropenem have?
Meropenem is a broad-spectrum carbapenem antibiotic that possesses excellent activity against both aerobic Gram-positive and aerobic Gram-negative bacteria, and also covers common anaerobes.
What ertapenem does not cover?
Spectrum: Like its big brother (Imipenem), ertapenem has a very broad spectrum of activity that includes all anaerobes and many aerobic gram-positive and gram-negative organisms. It has poor activity against P aeruginosa and Acinetobacter and lacks activity against Enterococcus faecium, S. epidermidis, B. Lepacia, S.
What are carbapenems for?
Carbapenems are a class of highly effective antibiotic agents commonly used for the treatment of severe or high-risk bacterial infections. This class of antibiotics is usually reserved for known or suspected multidrug-resistant (MDR) bacterial infections.
How is carbapenem-resistant detected?
Most of the molecular techniques for detecting carbapenem-resistance are PCR-based methods. They are used as a reference method to confirm or to address the problems in some results obtained from phenotypic detection methods.
Is imipenem a carbapenem?
Imipenem/cilastatin is the first of a new class of beta-lactam antibiotics called carbapenems. The antibacterial spectrum of imipenem exceeds any antibiotic investigated to date and includes gram-positive, gram-negative, and anaerobic organisms.
Does carbapenem cover MRSA?
Imipenem, a carbapenem, does not have bactericidal action against MRSA but it has a broad antibacterial spectrum covering both Gram-positive and Gram-negative bacteria, and has a stronger bactericidal activity than other β-lactams.
Is ertapenem a carbapenem?
Ertapenem is a new carbapenem developed to address the pharmacokinetic shortcomings (short half-life) of imipenem and meropenem. Ertapenem shares similar structural features with meropenem, including its stability to dehydropeptidase-1, allowing it to be administered without a dehydropeptidase-1 inhibitor.
Is colistin a carbapenem?
Colistin is the mainstay of therapy for carbapenem-resistant Enterobacteriaceae and is often the last available active antimicrobial agent (12).
What kind of coverage does carbapenem 2 have?
All carbapenems have fairly good coverage against anaerobes. Although they can be used for intra-abdominal infections, they are not always first-line therapy for this indication. Atypical Coverage1,2 Carbapenems do not cover atypical bacteria because these bacteria lack a cell wall that carbapenems attack.
What are carbapenems and what do they do?
Carbapenems are a class of atypical β-lactam antibiotics with broad-spectrum high antibacterial activity, excellent coverage of many Gram-positive and Gram-negative aerobic and anaerobic bacteria, and stable to most β-lactamases.
Why are carbapenems used for multidrug resistant infections?
This class of antibiotics is usually reserved for known or suspected multidrug-resistant (MDR) bacterial infections. Similar to penicillins and cephalosporins, carbapenems are members of the beta lactam class of antibiotics, which kill bacteria by binding to penicillin-binding proteins, thus inhibiting bacterial cell wall synthesis.
Why are carbapenems do not cover atypical bacteria?
Carbapenems do not cover atypical bacteria because these bacteria lack a cell wall that carbapenems attack. Clinical Pearls1,2 Imipenem has the highest risk for seizure across the carbapenems. Imipenem is broken down in the kidneys to a toxic metabolite by the DHP-1 enzyme.