What is Wilkinson syndrome?
Wilkinson’s syndrome (also known as Sclerotic pedicle sign) is a radiographic term which describes a unilaterally enlarged pedicle opposite a contralateral pars defect. The enlarged pedicle may due to stress hypertrophy, and changes may extend into the adjacent lamina and transverse processes.
What causes Subcorneal pustular dermatosis?
The cause of subcorneal pustular dermatosis is unknown. It is not caused by infection and is not contagious or cancerous. Most often it occurs on its own, but has been linked to a variety of other diseases, for example inflammatory bowel disease, arthritis, thyroid disease and blood disorders.
How do you treat Subcorneal pustular dermatosis?
Acitretin. Acitretin (and formally etretinate) has been used to successfully treat subcorneal pustular dermatosis (SPD) and should be considered as an alternative or additional treatment for those who are intolerant of, or unresponsive to, dapsone.
What does Subcorneal mean?
Subcorneal pustular dermatosis (SPD) is a rare skin disease in which pus-filled pimples or blisters (pustules) form under the top (subcorneal) layer of the skin. It is most common in middle-aged adults (particularly women) but can develop in children.
What is Exanthematous Pustulosis?
Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic pustuloderma) is a rare skin reaction that in 90% of cases is related to medication administration. AGEP is characterized by sudden skin eruptions that appear on average five days after a medication is started.
What is Subcorneal pustular dermatosis?
Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare neutrophilic dermatosis in which recurrent crops of sterile pustules appear in the most superficial (subcorneal) layers of the skin (picture 1A-B).
What does a pustular rash look like?
Pustules are easy to identify. They appear as small bumps on the surface of your skin. The bumps are usually white or red with white in the center. They may be painful to the touch, and the skin around the bump may be red and inflamed.
What drugs cause Exanthematous Pustulosis?
Although many causative factors leading to AGEP have been described, it is, in over 90% of cases, associated with the ingestion of drugs [5,6]. Aminopenicillins, pristinamycin, sulphonamides, quinolones, hydroxychloroquine, terbinafin and diltiazem are the most frequent causative drugs [7].
How do you get rid of acute generalized Exanthematous Pustulosis?
Acute generalized exanthematous pustulosis (AGEP) is most commonly caused by antibiotics (eg, aminopenicillins, macrolides, cephalosporins) followed by calcium channel blockers. The main treatment of AGEP is discontinuation of the culprit medication, which typically results in resolution within 2 weeks.
What is Linear IgA dermatosis?
Linear IgA bullous dermatosis (LABD) is a mucocutaneous autoimmune disease that may be drug-induced or idiopathic. It is characterized by linear deposition of IgA and disruption of the dermoepidermal junction, resulting in blisters with a tense clinical appearance.
What are the symptoms of subcorneal pustular dermatosis?
[3] The main symptom of subcorneal pustular dermatosis (SPD) is an outbreak of round bumps on the skin that may resemble pus-filled pimples or blisters (pustules). [1] [2] The pustules appear over a short period of time (hours), usually on healthy skin, but sometimes on skin that is irritated or inflamed.
How is subcorneal pustular dermatosis different from Sneddon-Wilkinson disease?
Subcorneal pustular dermatosis is also known as Sneddon-Wilkinson disease. It is a rare condition, characterised by pustules that appear in crops over months or years. In some cases, subcorneal pustular dermatosis may be later diagnosed as generalised pustular psoriasis; generalised pustular psorasisis tends to be a more serious condition.
What kind of skin disease is pustular dermatosis?
Subcorneal pustular dermatosis (SPD) is a rare skin disease in which pus-filled pimples or blisters (pustules) form under the top (subcorneal) layer of the skin.
What causes the formation of pustules in SPD?
While there are known triggers of neutrophil recruitment for some NDS, no specific triggers have been found to cause the pustule formation in SPD. An exception is rare cases associated with the use of certain medications. [2] [5] • Autoimmune diseases such as rheumatoid arthritis, lupus, and Sjogren syndrome.