What is the use of Cisatracurium?

What is the use of Cisatracurium?

Cisatracurium is used to relax the muscles to help keep your body still during surgery. Cisatracurium also relaxes your throat so a breathing tube can be more easily inserted before the surgery.

What is the difference between atracurium and Cisatracurium?

The same dose (2×ED95 dose) atracurium is more effective neuromuscular blocking agent than cisatracurium, while higher doses of cisatracurium 4×ED95 and 6×ED95 provide more effective, more rapid neuromuscular blocking with longer duration of action, stable hemodynamic status, and no associated signs of histamine …

What is Hofmann elimination of Cisatracurium?

Hofmann elimination, an organ independent elimination pathway, occurs in plasma and tissue, and is responsible for approximately 77% of the overall elimination of cisatracurium besilate.

How long can you use Cisatracurium?

Cisatracurium should be kept refrigerated at 2 to 8 degrees Celsius and protected from light to preserve potency. The rate of loss of potency is as high as 5% per month at 25 degrees Celsius. Once removed from refrigeration to room temperature storage, it should be used within 21 days.

How do you use Cisatracurium?

As in adults, the recommended intubation dose of Cisatracurium is 0.15 mg/kg (body weight) administered rapidly over 5 to 10 seconds. This dose produces good to excellent conditions for tracheal intubation 120 seconds following injection of Cisatracurium.

How do you mix Cisatracurium?

Cisatracurium Besylate Injection should not be diluted in Lactated Ringer’s Injection, USP due to chemical instability. EXP: 1 DAY (RT/REF). [Supplied: 10mg/ 5ml and 20 mg/10 ml vials (In refrigerator)]. Usual dilution: 0.1 to 0.4 mg/ml.

Which drug undergoes Hoffman’s elimination?

Atracurium, a nondepolarizing muscle relaxant, is eliminated through several pathways, including Hofmann elimination (spontaneous degradation in plasma and tissue at normal body pH and temperature) and ester hydrolysis (catalysis by nonspecific esterases).

When does Hofmann elimination occurs?

Hofmann elimination is an elimination reaction of an amine where the least stable (least substituted) alkene, the Hofmann product, is formed. This tendency, known as the Hofmann alkene synthesis rule, is in contrast to usual elimination reactions, where Zaitsev’s rule predicts the formation of the most stable alkene.

Does NIMBEX lower heart rate?

Nimbex side effects slow heart rate; dizziness; or. flushing (warmth, redness, or tingly feeling).

Can Cisatracurium be used for RSI?

High dose Cisatracurium at 0.4 mg/kg (8×ED95) is routinely used for rapid sequence induction when needed. of drug effect to match the anticipated length of surgery and to avoid unwanted cardiovascular side effects. time and tracheal intubation conditions.