What type of epithelium is bile duct?
Cholangiocytes are the epithelial cells of the bile duct. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.
What are interlobular bile ducts?
The interlobular bile ducts (or interlobular ductules) carry bile in the liver between the Canals of Hering and the interlobar bile ducts. They are part of the interlobular portal triad and can be easily localized by looking for the much larger portal vein.
What are bile canaliculi lined with?
cuboidal epithelium
The bile canaliculi drain through short bile ductules (cholangioles), partially lined by cuboidal epithelial cells, to bile ducts, lined with simple cuboidal epithelium, which course along with branches of the portal vein and hepatic artery in portal tracts.
What are biliary epithelial cells?
Biliary epithelial cells (BEC), or cholangiocytes, line a complex tree-like 3-dimensional network of conduits within the liver that form the biliary tract. The extrahepatic biliary tract is composed of the gallbladder, common hepatic duct, common bile duct, and cystic duct [2].
Which is the stretchable and waterproof epithelium?
Transitional epithelium is stretchable and waterproof. The cells of transitional epithelium are highly keratinized and contain tight junctions or virtually impenetrable junctions, that seal together the cellular membranes of neighboring cells.
What is a florid duct lesion?
The florid duct lesion, defined as a granulomatous destruction of the bile ducts, is the histological hallmark of PBC. The granulomatous inflammation may be either well-formed or vague, and is accompanied by lymphocytes and variable numbers of plasma cells, all of which are centered on the bile duct [6].
What is biliary canaliculi system?
Bile canaliculus (plural:bile canaliculi; also called bile capillaries) is a thin tube that collects bile secreted by hepatocytes. The bile canaliculi empty into a series of progressively larger bile ductules and ducts, which eventually become common hepatic duct.
How are bile salts made?
Bile salts are produced by the hepatocyte cells in the liver and are derived from cholesterol. When an alkaline substance meets an acid, it causes a neutralizing reaction. This reaction produces water and the chemical salts called bile salts.
What are the components of the biliary epithelium?
The biliary epithelium is composed of three main components: intrahepatic bile ducts, extrahepatic bile ducts, and peribiliary glands (PBGs) [15 ]. The intrahepatic bile ducts, which originate in the liver at the canals of Hering as small ductules, can be classified as either small or large bile ducts [ 16–18 ].
Where are the bile ducts located in the liver?
The interlobular bile ducts (or interlobular ductules) carry bile in the liver between the Canals of Hering and the interlobar bile ducts. They are part of the interlobular portal triad and can be easily localized by looking for the much larger portal vein.
Where are interlobular ductsare found in connective tissue?
Interlobular ductsare found between lobules, within the connective tissue septae. They vary considerably in size. The smaller forms have a cuboidal epithelium, while a columnar epithelium lines the larger ducts.
Is the cytoplasm of a bile duct uniform?
Although the individual bile ducts may be slightly irregular in shape, the epithelium lining these ducts is usually homogeneous in cell size and shape. The cells are cuboidal, similar to normal intrahepatic bile duct epithelium. The cytoplasm is lightly basophilic, and nuclei are uniform in size and shape.
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