What drugs does Andexxa reverse?
Coagulation factor Xa (recombinant), inactivated-zhzo (andexanet alfa; Andexxa – Portola) has received accelerated approval from the FDA for urgent reversal of the anticoagulant effect of the direct factor Xa inhibitors apixaban (Eliquis) and rivaroxaban (Xarelto).
When do you use Andexanet?
Andexanet alfa is indicated for anticoagulation reversal in life-threatening or uncontrolled bleeding in patients treated with rivaroxaban or apixaban.
Who makes Andexanet Alfa?
The US Food and Drug Administration (FDA) has cleared andexanet alfa (Andexxa) as a reversal agent for the anticoagulant effects of the two most commonly used factor Xa inhibitors in patients with life-threatening or uncontrolled bleeding, manufacturer Portola Pharmaceuticals announced late yesterday.
Is Andexanet Alfa available in India?
South Delhi Pharma can facilitate the supply of “ANDEXXA ® (coagulation factor Xa (recombinant), inactivated-zhzo)” to all locations in India and other part of countries after fulfilling the legal requirement (if applicable). All Anticancer drugs available upon request.
When to use Andexxa Andexanet alfa injections?
ANDEXXA (coagulation factor Xa (recombinant), inactivated-zhzo) is a recombinant modified human factor Xa (FXa) protein indicated for patients treated with rivaroxaban or apixaban, when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding. ( 1)
How does Andexanet alfa reverse factor Xa effects?
Andexanet alfa (andexanet) has been designed and developed specifically to reverse the effects of both direct and indirect factor Xa inhibitors. It is a recombinant, modified human factor Xa decoy protein that binds factor Xa inhibitors but does not have intrinsic catalytic activity.
How long does it take for andexanet to work?
Bleeding was predominantly gastrointestinal or intracranial. The mean (±SD) time from emergency department presentation to the administration of the andexanet bolus was 4.8±1.8 hours.
What kind of powder is used for Andexxa?
ANDEXXA is available as a white to off-white lyophilized powder in single-use vials of 200 mg of coagulation factor Xa (recombinant), inactivated-zhzo. ANDEXXA is available as a white to off-white lyophilized powder in single-use vials of 200 mg of coagulation factor Xa (recombinant), inactivated-zhzo. None. None.