Is ertapenem broad spectrum?
Conclusion: Ertapenem is a broad-spectrum parenteral antibiotic with activity against many Gram-negative (including Enterobacteriaceae) and Gram-positive aerobic and anaerobic bacteria and is suitable for once-daily administration.
What is the spectrum of meropenem?
Antibacterial spectrum of activity. Meropenem is a broad-spectrum carbapenem antibiotic that possesses excellent activity against both aerobic Gram-positive and aerobic Gram-negative bacteria, and also covers common anaerobes.
What bacteria does ertapenem not cover?
Spectrum: Like its big brother (Imipenem), ertapenem has a very broad spectrum of activity that includes all anaerobes and many aerobic gram-positive and gram-negative organisms. It has poor activity against P aeruginosa and Acinetobacter and lacks activity against Enterococcus faecium, S. epidermidis, B.
What bacteria does ertapenem cover?
Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria.
What is the difference between meropenem and ertapenem?
Invanz (ertapenem) is an antibiotic that’s usually only given in hospital for serious infections. Treats bacterial infections. Merrem (meropenem) is an antibiotic that’s usually only given in the hospital for serious infections. It can be given at home, but you’ll have to be taught how to inject it correctly.
Does ertapenem have CNS coverage?
After transition to ertapenem, subgaleal cultures were sterilized and the patient’s infection was resolved. This report suggests ertapenem may be a viable option for central nervous system infections; however, further study is needed.
What is broad spectrum antibiotics?
The term “broad spectrum antibiotics” was originally used to designate antibiotics that were effective against both gram-positive and gram-negative bacteria, in contrast to penicillin, which is effective chiefly against gram-positive organisms, and streptomycin, which is active primarily against gram-negative bacteria.
Is ertapenem and meropenem the same?
Ertapenem is similar to meropenem and imipenem in its activity against aerobic gram-positive and anaerobic organisms but is less active against non-fermentative Gram-negative bacilli 7, 8.
Does ertapenem cover B fragilis?
Ertapenem and piperacillin/tazobactam are beta-lactam antibiotics with a broad spectrum of activity used for the treatment of mixed infections in which Bacteroides fragilis and Escherichia coli play an important aetiological role.
What is the pH of ertapenem?
The sodium content is approximately 137 mg (approximately 6.0 mEq). Each vial of INVANZ contains the following inactive ingredients: 175 mg sodium bicarbonate and sodium hydroxide to adjust pH to 7.5.
Is ertapenem better than meropenem?
In general for these target pathogens, based on MIC90 values, ertapenem has similar potency to meropenem and is slightly more potent than imipenem against Gram-negative pathogens whereas imipenem is slightly more potent against Gram-positive pathogens.
Is ertapenem same as Invanz?
For Injection: Vials INVANZ is a sterile lyophilized powder in a single-dose vial containing 1 g ertapenem equivalent to 1.046 g ertapenem sodium for intravenous infusion or for intramuscular injection after reconstitution.
What is the mechanism of action of ertapenem?
Pharmacology and mechanism of action. Ertapenem is a beta-lactam antibiotic of the carbapenem (penem) class with a broad spectrum of activity. Its action on cell walls is similar to other beta-lactams, which is to bind penicillin-binding proteins (PBPs) that weaken or interfere with cell wall formation.
What kind of antibiotic is ertapenem beta lactam?
Mark G. Papich DVM, MS, DACVCP, in Saunders Handbook of Veterinary Drugs (Fourth Edition), 2016 Ertapenem is a beta-lactam antibiotic of the carbapenem (penem) class with a broad spectrum of activity.
Which is a better antibiotic ertapenem or nosocomial?
The unique antimicrobial spectrum and pharmacokinetic properties of ertapenem make it more suited to treatment of community-acquired infections and outpatient intravenous antimicrobial therapy than for the treatment of nosocomial infections.
Is there a link between ertapenem and CNS toxicity?
Carbapenems, including ertapenem, have been associated with central nervous system (CNS) toxicity. Most ertapenem CNS toxicity studies have excluded patients receiving hemodialysis (HD).