What causes nephrogenic metaplasia?
Nephrogenic metaplasia, a reactive urothelial lesion composed predominantly of tubular structures superficially resembling renal tubules, usually occurs in association with chronic inflammation induced by chronic irritation or trauma to the urothelium (1, 2, 3, 4).
What is nephrogenic metaplasia?
Nephrogenic metaplasia describes a lesion in the lower urinary tract that is composed of small tubules resembling renal medullary tubules. It has been suggested that nephrogenic metaplasia may progress to clear cell adenocarcinoma but this possibility is not widely accepted.
What is Nephrogenic bladder?
Nephrogenic adenoma of the urinary bladder is defined as a metaplastic change in the urinary bladder with papillary or cryptic structures which are composed of small hollow tubules similar to mesonephric tubules, which are usually lined by a single layer of bland cuboidal or hobnail cells, surrounding eosinophilic or …
Is cystitis Glandularis cancerous?
Individuals with diffuse intestinal-type cystitis glandularis are at increased risk for developing bladder cancer.
What is the treatment for nephrogenic diabetes insipidus?
Treatment of Nephrogenic Diabetes Insipidus Treatment consists of ensuring adequate free water intake; providing a low-salt, low-protein diet; and correcting the cause or stopping any likely nephrotoxin. Serious sequelae are rare if patients can drink at will.
What is nephrogenic rest?
Nephrogenic rests (NR) are abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney. Though NR are best known as precursors of Wilms tumor (WT), many alternative fates are observed, and most rests are destined for eventual atresia.
What does nephrogenic mean?
Medical Definition of nephrogenic 1 : originating in the kidney : caused by factors originating in the kidney nephrogenic hypertension. 2 : developing into or producing kidney tissue strands of nephrogenic cells.
What is Nephrogenic cord?
The nephrogenic cord is a portion of the urogenital ridge which is the source of much of the urinary system. The nephrogenic cords are bilateral condensations of the intermediate mesoderm. The cords extend from the cervical segments to the sacral segments of the embryo.
Can cystitis glandularis be cured?
This may be related to the fact that the primary disease is cured by ureteroscopic surgery, which could promote healing of lesions on bladder in cystitis glandularis. The remaining 2 patients refused treatment. Cystitis glandularis is often accompanied by other diseases; therefore its treatment cannot be ignored.
What is cystitis glandularis in the bladder?
Cystitis glandularis is a proliferative disorder of the urinary bladder in which there is glandular metaplasia of the transitional cells lining the urinary bladder. This entity is closely related to cystitis cystica, with which it commonly co-exists.
What happens in nephrogenic diabetes insipidus?
In nephrogenic diabetes insipidus, the kidneys produce a large volume of dilute urine because the kidney tubules fail to respond to vasopressin (antidiuretic hormone) and are unable to reabsorb filtered water back into the body.
What causes nephrogenic metaplasia in the urinary tract?
Commonly appears to be metaplastic and associated with secondary urothelial injury, such as past surgery (60%), calculi (14%) or trauma including chronic catheterization (9%) and urinary tract infection ( Hum Pathol 1981;12:907 )
Is it normal to have metaplasia of the bladder?
Metaplasia is common in the urothelium of the bladder, and in many instances it is a normal finding or is a reversible change in response to injury. The majority of metaplasias are reversible and are not premalignant (Table 1).
What is the name of the metaplastic condition in the ureter?
Cystosocopic appearances of A) Cystitis cystica and B) Vaginal squamous metaplasia with demarcation between the whitish metaplastic tissue and normal urothelium easily seen. When this condition occurs in the ureter, it is known as uretreitis cystica or ureteritis glandularis depending on the predominant proliferation.
Which is a nonneoplastic change in the urothelium?
Nonneoplastic localized or diffuse, papillary, tubular or cystic metaplastic changes of the urothelium in response to chronic infection, calculi, injury or prolonged catheterization Characterized by a single layer of cuboidal or hobnail epithelial cells with clear or eosinophilic cytoplasm and small, discrete nuclei without prominent nucleoli