What is the function of granulocyte colony stimulating factor?
Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.
Where is granulocyte colony stimulating factor?
G-CSF is produced by endothelium, macrophages, and a number of other immune cells.
What is G-CSF Mobilization?
Granulocyte colony-stimulating factor (G-CSF) has been routinely used to therapeutically mobilize hematopoietic stem cells (HSC) to the bloodstream for transplantation for over two decades. These studies showed release of active proteases in the bone marrow (BM) in response to G-CSF or CYP.
What is G-CSF also mention its application?
G-CSF is currently used for the haematological support of cancer patients receiving chemotherapy, but it is not an anticancer treatment. The use of G-CSF allows patients to receive the intended dose of chemotherapy without reductions or an increased dose.
What is Interleukin used for?
interleukin (IL), any of a group of naturally occurring proteins that mediate communication between cells. Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation.
What is Lenograstim used for?
Lenograstim is the glycosylated recombinant form of human granulocyte colony stimulating factor. The drug is used to reduce the risk of life-threatening infection in patients with neutropenia, particularly after cytotoxic chemotherapy.
What are the side effects of Nivestim?
The most common side effects with Nivestim (which may affect more than 1 in 10 people) are fever, musculoskeletal pain (pain in the muscles and bones), anaemia (low red blood cell counts), vomiting and nausea (feeling sick).
What is stem cell mobilization?
Listen to pronunciation. (stem sel MOH-bih-lih-ZAY-shun) A process in which certain drugs are used to cause the movement of stem cells from the bone marrow into the blood. The stem cells can be collected and stored.
What are granulocytes?
A type of immune cell that has granules (small particles) with enzymes that are released during infections, allergic reactions, and asthma. Neutrophils, eosinophils, and basophils are granulocytes. A granulocyte is a type of white blood cell. Also called granular leukocyte, PMN, and polymorphonuclear leukocyte.