What is a disadvantage of a live attenuated viral vaccine?
Disadvantages: Because they contain living pathogens, live attenuated vaccines are not given to people with weakened immune systems, such as people undergoing chemotherapy or HIV treatment, as there is a risk the pathogen could get stronger and cause sickness.
What are the contraindications for live vaccines?
A severe allergic reaction (e.g., anaphylaxis) to a vaccine component is a contraindication to any vaccine containing that component, and a severe allergy following a dose of vaccine is a contraindication to subsequent doses of that vaccine. Severe immunosuppression is a contraindication to live, attenuated vaccines.
Who should not receive live attenuated vaccines?
Severely immunocompromised persons generally should not receive live vaccines (3). Because of the theoretical risk to the fetus, women known to be pregnant generally should not receive live, attenuated virus vaccines (4).
Are live attenuated vaccines safe for immunocompromised patients?
Live attenuated influenza vaccine should not be administered to immunocompromised persons.
What is the major disadvantage of attenuated vaccines?
The major disadvantage of attenuated vaccines is that secondary mutations can lead to reversion to virulence and can thus cause disease. There is another possibility of interference by related viruses, as is suspected in the case of oral polio vaccine in developing countries.
Are all live vaccines attenuated?
Inactivated. Live vaccines are derived from “wild” viruses or bacteria. These wild viruses or bacteria are attenuated (weakened) in a laboratory, usually by repeated culturing. For example, the measles virus used as a vaccine today was isolated from a child with measles disease in 1954.
What are contraindications for vaccination with the live attenuated MMR vaccine?
MMR and MMRV vaccines are contraindicated in people who have had:
- anaphylaxis after a previous dose of any MMR -containing vaccine.
- anaphylaxis after any component of an MMR -containing vaccine.
What is the difference between live attenuated vaccines and inactivated vaccines?
An inactivated vaccine works when the immune system responds to a piece of a bacteria or virus or to a toxin produced by the germ. Live “attenuated” vaccines mean they have been changed such that they do not cause disease.
What are precautions and contraindications?
A contraindication means that a vaccine should not be administered. A precaution identifies a situation in which a vaccine may be administered if the benefit from the vaccine is judged to outweigh the risk.
What is the difference between live and attenuated vaccines?
Which vaccines should I avoid if immunocompromised?
Live virus vaccines are usually not safe if you are immunocompromised….Some common examples of live virus vaccines are:
- Measles, mumps, and rubella (MMR)
- Varicella (chickenpox vaccine)
- The live attenuated influenza vaccine, also known as the nasal flu vaccine (FluMist Quadrivalent)
- Yellow fever.
- Rotavirus.
Why should immunosuppressed patients not receive live vaccine?
Live attenuated vaccines should not be given to people who are clinically immunosuppressed (either due to drug treatment or underlying illness) because the vaccine strain could replicate too much and cause an extensive, serious infection.