What causes the pituitary gland to produce too much TSH?
Having an overactive pituitary gland is called hyperpituitarism. It is most commonly caused by noncancerous tumors. This causes the gland to secrete too much of certain kinds of hormones related to growth, reproduction, and metabolism, among other things.
What hormone is secreted by the pituitary adenoma?
Approximately half of pituitary adenomas secrete distinct pituitary hormones (most often prolactin, growth hormone, or adrenocorticotropic hormone). While these tumors are histologically benign, they have potent endocrine effects that lead to significant morbidity and shortened lifespan.
What is TSH adenoma?
A TSH-producing pituitary adenoma is one that makes too much thyroid-stimulating hormone, which stimulates the thyroid gland to produce the thyroid hormones (T4 and T3). These hormones regulate metabolism and affect the growth and rate of function of other organs.
Does pituitary gland release TSH?
The hypothalamus and the pituitary gland, which are located in the brain, help control the thyroid gland. The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid-stimulating hormone (TSH).
What happens when TSH levels are high?
High TSH levels can mean your thyroid is not making enough thyroid hormones, a condition called hypothyroidism. Low TSH levels can mean your thyroid is making too much of the hormones, a condition called hyperthyroidism.
How do you treat TRH secreting tumors?
The most common initial therapy for patients with a TSH-secreting pituitary adenoma is transphenoidal resection of the tumour. This is an operation whereby the tumour is removed via the nasal cavity. Transcranial (through the skull) resection of the tumour may be performed for very large tumours.
What is a secreting pituitary tumor?
Pituitary tumor Pituitary tumors are abnormal growths that develop in your pituitary gland. Some pituitary tumors result in too much of the hormones that regulate important functions of your body. Some pituitary tumors can cause your pituitary gland to produce lower levels of hormones.
What two hormones are produced by the pituitary gland?
The major hormones produced by the pituitary gland are:
- ACTH: Adrenocorticotrophic hormone.
- FSH: Follicle-stimulating hormone.
- LH: Luteinizing hormone.
- GH: Growth hormone.
- PRL: Prolactin.
- TSH: Thyroid-stimulating hormone.
What happens when TSH is high?
If your TSH levels are abnormally high, it could mean you have an underactive thyroid, or hypothyroidism. That’s because it indicates your pituitary gland is producing more TSH in an effort to stimulate your thyroid to produce thyroid hormone, according to the Mayo Clinic.
What happen if TSH is high?
Is TSH secreted by the posterior pituitary?
Thyroid-Stimulating Hormone TSH is released from the anterior pituitary in response to thyrotropin-releasing hormone (TRH) from the hypothalamus. As discussed shortly, it triggers the secretion of thyroid hormones by the thyroid gland.
Does high TSH indicate pituitary tumor?
If a person already as an existing thyroid condition, then a high TSH level means that you need to increase the dosage of the thyroid medication. Rarely, high TSH levels can also be an indication of a tumor, which is causing the overproduction of TSH from the pituitary gland.
What does high TSH Thyroid mean?
A high TSH result often means an underactive thyroid gland caused by failure of the gland (hypothyroidism). Very rarely, a high TSH result can indicate a problem with the pituitary gland, such as a tumour, in what is known as secondary hyperthyroidism .
What is the prognosis for people with pituitary tumors?
The prognosis for a pituitary tumor is generally good if the tumor and the hormones it may be secreting in excess and the destructive effects of the tumor on the endocrine function of the pituitary can be controlled.
What is the prognosis of pituitary macroadenomas?
Microadenomas do not cause excess mortality. These tumors generally are too small to cause pain, diplopia, or pressure on the optic chiasm. Otherwise-normal anterior and posterior pituitary function remains intact. Any morbidity is caused by excessive hormone secretionor patient anxiety.