How effective is Casodex?
The efficacy and tolerability of Casodex, a new non-steroidal antiandrogen, were studied in 267 patients with advanced prostate cancer. All patients received Casodex, 50 mg daily, as monotherapy. The objective response rate was 55.5% and the subjective response rate was 56.1%.
What is the half life of Casodex?
Casodex has a half-life of approximately 1 week, enabling once-daily dosing with no effect of age or renal impairment on its pharmacokinetics.
Is xtandi better than Casodex?
Xtandi Superior to Casodex for Hormone Refractory Prostate Cancer. The agent Xtandi® improves survival and reduces the time to cancer progression compared to Casodex® (bicalutamide) among men with prostate cancer that has stopped responding to prior therapy with anti-androgens.
Can Casodex lower PSA?
A subset of patients who stop Casodex treatment develop antiandrogen withdrawal syndrome, this is when after stopping Casodex the patient has a decrease in prostate-specific antigen (PSA) and they may benefit from a clinical improvement.
How long does it take Casodex to work?
You should empty your bladder (urinate) before taking the medication. In some cases (e.g. spinal cord metastasis), Casodex will be started approximately 5-7 days before you receive the LHRH agonist. This is done to block the “flare” or surge of testosterone that occurs after LHRH agonist is given.
How long is Casodex effective?
by Drugs.com Casodex (bicalutamide) is a medicine that you take long term. In a clinical trial the median follow up time was 160 weeks (approximately 3 years). The length of time you may be on Casodex will be depend on: cancer stage.
Does bicalutamide reduce PSA?
Androgen suppression with bicalutamide 50 mg daily for 24 weeks resulted in a median of 56% reduction of PSA (P<0.001 when compared to placebo).
Is bicalutamide the same as enzalutamide?
Enzalutamide, a potent oral androgen receptor inhibitor, improves survival in men with metastatic castration-resistant prostate cancer (CRPC) before and after chemotherapy. Bicalutamide, a nonsteroidal antiandrogen, is widely used to treat men with nonmetastatic or metastatic CRPC.
What drugs are used for androgen deprivation therapy?
LHRH agonists and antagonists used in androgen deprivation therapy include leuprorelin, goserelin, triptorelin, histrelin, buserelin, and degarelix. These drugs are injected under the skin achieving the same result as surgical castration.
What is the highest PSA level a man can have?
Understanding Your PSA Test
- 0 to 2.5 ng/mL is considered safe.
- 2.6 to 4 ng/mL is safe in most men but talk with your doctor about other risk factors.
- 4.0 to 10.0 ng/mL is suspicious and might suggest the possibility of prostate cancer.
- 10.0 ng/mL and above is dangerous and should be discussed with your doctor immediately.
What are the chances of survival after taking Casodex?
After 160 weeks, 47.3% of the men who took Casodex were still alive, compared with 42.5% of the men who took flutamide. The researchers found that the difference in survival rates between the two groups was not significant. (This means the difference was likely due to chance.)
Which is better for prostate cancer, Casodex or flutamide?
A clinical study found Casodex to be as effective as a drug called flutamide for treating metastatic prostate cancer. Flutamide is an anti-androgen drug that works in the same way as Casodex. It’s a standard treatment option for metastatic prostate cancer, recommended in guidelines from the National Comprehensive Cancer Network.
What kind of drug is Casodex used for?
Casodex is a type of drug called an androgen receptor inhibitor, or anti-androgen. It blocks the action of testosterone on the cancer cells. Casodex is used with another type of hormone therapy, called a luteinizing hormone-releasing hormone (LHRH) analog. These drugs lower the amount of testosterone in your body.
Are there any side effects to generic Casodex?
Casodex contains the active drug bicalutamide. This drug is also available in generic form. Generic tablets come in the same strength as Casodex (50 mg). A generic drug is an exact copy of a brand-name medication. Generics tend to cost less than brand-name drugs. Casodex can cause mild or serious side effects.