What do you need to know about gentamicin injections?
Gentamicin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract.
Where is gentamicin found after parenteral administration?
Following parenteral administration, gentamicin can be detected in serum, lymph, tissues, sputum and in pleural, synovial and peritoneal fluids. Concentrations in renal cortex sometimes may be eight times higher than the usual serum levels.
When to adjust gentamicin dosage when monitoring peak concentrations?
When monitoring gentamicin peak concentrations, dosage should be adjusted so that prolonged levels above 12 mcg/mL are avoided. When monitoring gentamicin trough concentrations, dosage should be adjusted so that levels above 2 mcg/mL are avoided.
Is there a connection between gentamicin and liver injury?
Despite its wide use, gentamicin has not been definitively linked to instances of clinically apparent liver injury. Gentamicin is a broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora.
Is there a generic version of gentamicin available?
Gentamicin is currently on the World Health Organization’s List of Essential Medicines. The World Health Organization classifies gentamicin as critically important for human medicine. It is available as a generic medication.
What is the PKB of gentamicin in soil?
Using a structure estimation method based on molecular connectivity indices(1), the Koc of gentamicin can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that gentamicin is expected to have very high mobility in soil. The estimated pKb of gentamicin is 9.0(3),…
How to report side effects of gentamicin in Canada?
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before using gentamicin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such as tobramycin, amikacin); or if you have any other allergies.