What does Pecam 1 bind to?
Heterophilic binding partners of PECAM-1 include the integrin αVβ3,70–72 CD38,73 and the neutrophil-specific CD17774; however, the physiological relevance of these interactions to platelets is currently not clear.
What is CD31 staining?
Clinical Information CD31 (cluster of differentiation 31) is expressed on endothelial cells, showing some membrane and occasional cytoplasmic staining. It is not expressed on discontinuous endothelium (eg, splenic red pulp). It is also expressed on megakaryocytes, histiocytes, plasma cells, and T-cell subsets.
What is CD31 and CD34?
CD34 is one of the Endothelial Cell Differentiation Markers and Endothelial Progenitor Cell Markers. CD31 is normally found on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils.
Do all endothelial cells express CD31?
CD31 is expressed on platelets and on most leukocytes and is constitutively present on endothelial linings in vivo.
Is Pecam an integrin?
CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium. J Cell Biol. 1995 Jul;130(2):451-60.
What does CD31 positive mean?
In immunohistochemistry, CD31 is used primarily to demonstrate the presence of endothelial cells in histological tissue sections. This can help to evaluate the degree of tumor angiogenesis, which can imply a rapidly growing tumor.
What is CD31 a marker for?
CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM-1), is thought to be a sensitive and specific marker for vascular differentiation. 1,2. It is a transmembrane glycoprotein expressed by endothelial cells and a variety of hematopoietic cells.
What are CD31 positive cells?
CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM-1), is thought to be a sensitive and specific marker for vascular differentiation. It is a transmembrane glycoprotein expressed by endothelial cells and a variety of hematopoietic cells.
What does Pecam mean?
Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.
What is a primary function of integrins What is a primary function of integrins?
Integrins are the principal receptors used by animal cells to bind to the extracellular matrix. A cell can regulate the adhesive activity of its integrins from within. Integrins also function as signal transducers, activating various intracellular signaling pathways when activated by matrix binding.
Where is CD31 / PECAM-1 found in the cell?
CD31/PECAM-1 is a heavily glycosylated transmembrane homophilic adhesion protein that is highly expressed on endothelial cells and at a lower level on platelets, granulocytes, macrophages, dendritic cells, T and B cells, and NK cells. It is required for the transepithelial migration of leukocytes.
When is CD31 released in endothelial cells?
CD31 signaling increases the activation threshold of T cells and inhibits dendritic cell development. The extracellular domain of CD31 is released during endothelial cell apoptosis.
What is the function of PECAM-1 in endothelial cells?
Structurally, PECAM-1 consists of six extracellular immunoglobulin-like domains which serve to support various functions including homophilic binding, maintaining high expression of PECAM-1 within endothelial intercellular junctions, and supporting endothelial cell migration (1,2).
What can PECAM-1 antibodies be used for?
Antibodies that detect CD31 (PECAM-1) can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry View more