Does carfilzomib cause peripheral neuropathy?
Despite its notable efficacy, bortezomib has side effects like peripheral neuropathy (PNP) with reported incidence of grade ≥3 PNP between 2%-23% Schlafer et al., 2017. Carfilzomib (CFZ) has high selectivity and minimal off-target adverse effects including lower rates of PNP.
Does multiple myeloma cause neuropathy?
The disease process of myeloma can cause peripheral neuropathy in a few ways. It is thought that the myeloma protein (paraprotein) produced by the malignant plasma cells, can cause direct damage to the nerve cells, resulting in symptoms of neuropathy.
Does Revlimid cause peripheral neuropathy?
Thalomid® (thalidomide), Velcade® (bortezomib), Ninlaro® (ixazomib), and Pomalyst® (pomalidomide) can all cause peripheral neuropathy; Revlimid® (lenalidomide) may make pre-existing neuropathy worse.
Does melphalan cause peripheral neuropathy?
Melphalan-Prednisone-Lenalidomide Unlike with MPT and VMP, neuropathy is not a major adverse effect but major grade 3/4 adverse events are hematologic and include neutropenia, thrombocytopenia, and anemia. The median PFS was similar between MPR and MP at 14 months versus 13 months, respectively.
How long can you stay on carfilzomib?
The authors concluded that “compared with the overall results of the ASPIRE study, the markedly lower [hazard ratio] for PFS at 18 months in this analysis suggests a potential additional clinical benefit of continued treatment with carfilzomib beyond 18 months. However, further evaluation is warranted.”
Is carfilzomib better than bortezomib?
“There was no improvement in progression-free survival by replacing bortezomib with carfilzomib in the current standard initial treatment of patients with newly diagnosed standard- or intermediate-risk myeloma, even though we observed a higher very good partial response rate with the carfilzomib combination.”
What are the symptoms of dying from myeloma?
But when you have late-stage multiple myeloma, your symptoms may show up as:
- Being sick to your stomach.
- Bone pain in your back or ribs.
- Bruising or bleeding easily.
- Feeling very tired.
- Fevers.
- Frequent infections that are hard to treat.
- Losing a lot of weight.
- Not feeling like eating.
Is neuropathy a side effect of Revlimid?
Revlimid has a fairlylow incidence of neuropathy, but it does happen. Sometimes stopping the drug is the most important thing.
Does Revlimid cause muscle pain?
Treatment with REVLIMID can cause muscle cramps or spasms. People who get a muscle cramp experience a sudden, painful contraction of one or more of their muscles, and have no control over it. If you have muscle cramps or spasms, tell your doctor or nurse.
Is polyneuropathy the same as neuropathy?
Polyneuropathy is when multiple peripheral nerves become damaged, which is also commonly called peripheral neuropathy.
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