What is the sterocenter configuration of dextromethorphan?
Dextromethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a- (epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
What are the side effects of dextromethorphan in humans?
The main risks associated with dextromethorphan are ataxia, central nervous system (CNS) stimulation, dizziness, lethargy and psychotic behavior. Less frequently with large doses seizures and respiratory depression can occur. Nausea, vomiting, constipation and tachycardia may also occur.
What kind of cough can dextromethorphan be used for?
Dextromethorphan is used to treat a cough. It is available over-the-counter alone and is also present in many over-the-counter and prescription combination medications. Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.
When did dextromethorphan become an over the counter antitussive?
Dextromethorphan – StatPearls – NCBI Bookshelf Dextromethorphan received FDA approval in 1958 for its use as a cough suppressant. It is one of the most common compounds found in most over-the-counter antitussives for the past 50 years. In 2010, the FDA approved the use of dextromethorphan for pseudobulbar affect in combination with quinidine.
What kind of Medicine is dextromethorphan used for?
What is dextromethorphan? Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Dextromethorphan is used to treat a cough.
When does dextromethorphan exert its antitussive effect?
Dextromethorphan is rapidly absorbed from the GI tract and exerts its antitussive effect in 15-30 minutes after oral administration. The duration of action is approximately 3-6 hours with conventional dosage forms.
Are there any side effects to dextromethorphan in humans?
A rare side effect is respiratory depression. Dextromethorphan had been thought to cause Olney’s lesions when administered intravenously; however, this was later proven inconclusive, due to lack of research on humans. Tests were performed on rats, giving them 50 mg or more every day for as long as a month.