What Catie found results from the schizophrenia trial?
The most striking result of the CATIE study, which enrolled almost 1,500 individuals with chronic schizophrenia, was the high rate of treatment discontinuation (up to 74%) over the 18-month period of the trial and the short median time to discontinuation of treatment (about 6 months) in all phases of the trial.
What is CATIE trial?
It is designed for people with schizophrenia who may benefit from a medication change. The study involves the newer atypical antipsychotics (olanzapine, quetiapine, risperidone, clozapine, and ziprasidone)and the typical antipsychotics (perphenazine and fluphenazine decanoate).
How long is an antipsychotic trial?
An adequate trial of a typical antipsychotic is often defined as six weeks at a dosage level of 1000 mg/day in chlorpromazine (Thorazine) equivalents.
Does olanzapine cause weight gain?
Olanzapine and zotepine caused significantly more weight gain than most other antipsychotics. Another head-to-head meta-analysis reported that olanzapine and clozapine cause the highest amount of weight gain, while quetiapine, risperidone and sertindole caused intermediate amounts.
What is the most common negative symptom of schizophrenia?
Negative mental symptoms
- a seeming lack of interest in the world.
- not wanting to interact with other people (social withdrawal)
- an inability to feel or express pleasure (anhedonia)
- an inability to act spontaneously.
- decreased sense of purpose.
- lack of motivation (avolition)
- not talking much.
What Catie found?
The CATIE finding of no difference in tardive dyskinesia risk across treatment groups is consistent with the findings of a meta-analysis of 31 randomized controlled trials, which found no greater risk of extrapyramidal symptoms between low-potency first-generation antipsychotics and second-generation antipsychotics …
How many atypical antipsychotics are there?
There are 6 atypical antipsychotics commercially available in the United States: clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole.
What is the brand name for perphenazine?
Formulations. It is sold under the brand names Trilafon (single drug) and Etrafon/Triavil/Triptafen (contains fixed dosages of amitriptyline). A brand name in Europe is Decentan pointing to the fact that perphenazine is approximately 10-times more potent than chlorpromazine.
What is the strongest anti psychotic drug?
Clozapine, which has the strongest antipsychotic effect, can cause neutropenia. A problem in the treatment of schizophrenia is poor patient compliance leading to the recurrence of psychotic symptoms.
How long do you stay on olanzapine?
For psychosis or schizophrenia, if you have had one episode of illness, then it is best for you to keep taking olanzapine for at least two years to reduce the chances of becoming ill again. If you have had more than one episode of illness, then a period of at least five years is recommended.
What are the results of the CATIE trial?
In Phase 2, clozapine demonstrated better effectiveness compared to other SGAs for subjects who discontinued their Phase 1 medication because of efficacy. Olanzapine and risperidone showed greater effectiveness in the tolerability pathway. CATIE secondary outcomes are currently being examined.
What is the purpose of the CATIE schizophrenia trial?
CATIE- Schizophrenia Trial. The CATIE Schizophrenia Trial is part of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Project. The schizophrenia trial is being conducted to determine the long-term effects and usefulness of antipsychotic medications in persons with schizophrenia.
What was the purpose of the CATIE study?
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study was initiated by the NIMH to compare the effectiveness of antipsychotic drugs. Its rationale, design, and methods have been described previously.
When to use a sample reference letter template?
Use this sample reference letter when a colleague, former team member, student, or acquaintance asks for a personal recommendation. Be sure to modify this reference letter template with specific examples from your experience with that person.