What is NG2 positive cells?
NG2-positive cells include oligodendrocyte progenitor cells (OPCs) and other progenitor cell populations, such as chondroblasts, myoblasts, and pericytes, as well as several different tumors including glioblastoma multiforme and melanoma.
What cells express NG2?
NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J. Neurosci. 22, 2792–2803.
What does NG2 stain?
NG2 cells are abundant in the adult human brain and are distinct from microglia, oligodendrocytes, and astrocytes. NG2 antibodies stain relatively small perikarya, which emanate stellate-shaped processes that occupy discrete domains (A, arrowheads). NG2 is detected on endothelial cells also (A, arrows).
Do oligodendrocytes express NG2?
The evidence thus indicates that the majority of NG2-expressing cells generated during CNS development are indeed a part of the oligodendrocyte lineage and do give rise to oligodendrocytes.
What is NG2 angular?
ng2-admin is a front-end Admin Dashboard template based on Angular, Bootstrap 4 and Angular CLI. That means all the data you can see on graphs, charts and tables is mocked in Javascript so you can use the backend of your choice with no limitations.
Where are microglia found?
the central nervous system
Microglial cells are a specialised population of macrophages that are found in the central nervous system (CNS). They remove damaged neurons and infections and are important for maintaining the health of the CNS.
What do NG2 cells do?
NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 135, 145–157 (2008). Fate mapping of polydendrocytes using NG2–Cre-transgenic mice showed that the predominant fate of these cells is to differentiate into oligodendrocytes and a subset of protoplasmic astrocytes in the grey matter.
Can astrocytes express NG2?
In this model, astrocytes contain glial filaments with high or low levels of GFAP, but do not express NG2, and exhibit glutamate transporter activity. GFAP has never been detected in NG2-glia, nor has a transition from an NG2 glial cell into a GFAP+ cell been observed in vivo during development or in injury response.
Is ng2-charts open source?
The ng2-charts module is an open-source JavaScript library, and it is exclusively built for Angular 2+ and available via npm.
Is Chart js free to use?
js is a free open-source JavaScript library for data visualization, which supports 8 chart types: bar, line, area, pie (doughnut), bubble, radar, polar, and scatter. js renders in HTML5 canvas and is widely covered as one of the best data visualization libraries. It is available under the MIT license.
Where does NG2 come from in the body?
Recently, when co-localized with S100β, NG2 has been shown to be a marker of terminal, or perisynaptic, Schwann cells at the neuromuscular junction. Although NG2 is a single-pass transmembrane protein, it may also be released by proteolytic cleavage into the extracellular space where it associates with the extracellular matrix (ECM).
What kind of cells are NG2 positive cells?
NG2 proteoglycan. NG2-positive cells include oligodendrocyte progenitor cells (OPCs) and other progenitor cell populations, such as chondroblasts, myoblasts, and pericytes, as well as several different tumors including glioblastoma multiforme and melanoma.
What are the functions of the NG2 proteoglycan?
It is believed to play a role in functions such as cell adhesion, cell-cell and cell-ECM communication, migration and metastasis, proliferation, and axonal growth, guidance and regeneration.
Which is a homologous protein of the NG2 protein?
Neural/glial antigen 2, or NG2, is a rat integral membrane proteoglycan found in the plasma membrane of many diverse cell types. Homologous proteins in other species include human CSPG4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP), Mouse AN2, and Sea urchin ECM3.