What are Immunoproliferative disorders?
1: Immunoproliferative Disorders Disorders characterized by abnormal proliferation of primary cells of the immune system or by excessive production of immunoglobulins.
What is lymphoproliferative syndrome?
Description. Collapse Section. Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). ALPS is characterized by the production of an abnormally large number of lymphocytes (lymphoproliferation).
How does autoimmune disorder affect the endocrine system?
Autoimmunity affects multiple glands in the endocrine system. Animal models and human studies highlight the importance of alleles in HLA (human leukocyte antigen)-like molecules determining tissue specific targeting that with the loss of tolerance leads to organ specific autoimmunity.
What are the symptoms of lymphoproliferative disorder?
Approximately half of individuals with X-linked lymphoproliferative syndrome experience severe, life-threatening mononucleosis characterized by fever, inflammation and soreness of the throat (pharyngitis), swollen lymph glands, enlargement of the spleen (splenomegaly), enlargement of the liver (hepatomegaly), and/or …
What does Hypergammaglobulinemia mean?
Hypergammaglobulinemia is an uncommon condition that is usually the result of an infection, autoimmune disorder, or malignancy such as multiple myeloma. It’s characterized by elevated levels of immunoglobulins in your blood.
What causes Paraproteinemia?
Causes of paraproteinemia include the following: Leukemias and lymphomas of various types, but usually B-cell non-Hodgkin lymphomas with a plasma cell component. Idiopathic (no discernible cause): some of these will be revealed as leukemias or lymphomas over the years.
What is Duncan’s syndrome?
X-linked lymphoproliferative syndrome (XLP), or Duncan’s syndrome, is a rare genetic condition where the immune system does not work properly.
What is Evans syndrome?
Evans syndrome is a rare disorder in which the body’s immune system produces antibodies that mistakenly destroy red blood cells, platelets and sometimes certain white blood cell known as neutrophils. This leads to abnormally low levels of these blood cells in the body (cytopenia).
What are disorders of the endocrine system?
Common endocrine disorders include diabetes mellitus, acromegaly (overproduction of growth hormone), Addison’s disease (decreased production of hormones by the adrenal glands), Cushing’s syndrome (high cortisol levels for extended periods of time), Graves’ disease (type of hyperthyroidism resulting in excessive thyroid …
Is RA an endocrine disorder?
Endocrine Hormones in RA Several hormones are known to be involved or associated with inflammatory joint diseases such as RA, suggesting crosstalk between the endocrine hormones and immunity as recently highlighted (10). In addition, cortisol is known as the strongest endogenous anti-inflammatory hormone (11).
What are the types of lymphoproliferative disorders?
Lymphoproliferative disorders (examples)
- Follicular lymphoma.
- chronic lymphocytic leukemia.
- acute lymphoblastic leukemia.
- hairy cell leukemia.
- Hemophagocytic lymphohistiocytosis (HLH)
- B-cell lymphomas.
- T-cell lymphomas.
- multiple myeloma.
Is leukemia a lymphoproliferative disorder?
B-cell lymphoproliferative disorders are conditions in the blood involving uncontrolled growth of lymphocytes (white blood cells). These conditions include such cancers as multiple myeloma, Hodgkin lymphoma and chronic lymphocytic leukemia (CLL), and such precursor conditions as monoclonal B-cell lymphocytosis.