What is a normal soluble transferrin receptor?
Normal adult levels vary from 2 to 5 mg/l. However, pediatric studies are few and describe normal ranges to the tune of 1.0–3.0 mg/l, which are relatively lower than that of adults. In present study 40 healthy children (2–12 years) were evaluated to establish normal soluble transferrin receptor range.
What does low transferrin saturation indicate?
A transferrin saturation test tells us how much iron in the blood is bound to transferrin. A low transferrin saturation usually indicates iron deficiency while a high saturation often confirms haemochromatosis.
What does the serum protein transferrin do?
The main role of transferrin is to deliver iron from absorption centers in the duodenum and white blood cell macrophages to all tissues. Transferrin plays a key role in areas where erythropoiesis and active cell division occur.
Is ferritin and transferrin the same thing?
Ferritin is stored in the body’s cells until it’s time to make more red blood cells. The body will signal the cells to release ferritin. The ferritin then binds to another substance called transferrin. Transferrin is a protein that combines with ferritin to transport it to where new red blood cells are made.
What does a high soluble transferrin receptor mean?
iron deficiency
The level of soluble transferrin receptor (sTfR) will be increased with iron deficiency. If you have anemia and your sTfR level is elevated, then it is likely that you have iron deficiency anemia.
Why do soluble transferrin receptors increase in iron deficiency anemia?
Since the sTfR in serum is derived primarily from developing RBCs it not only reflects the degree of erythropoiesis but also the iron demand as erythroblasts in the bone marrow will increase the presentation of membrane transferrin receptor in the setting of iron deficiency.
What diseases cause low iron saturation?
Slow, chronic blood loss within the body — such as from a peptic ulcer, a hiatal hernia, a colon polyp or colorectal cancer — can cause iron deficiency anemia.
Is low transferrin bad?
However, markedly low transferrin levels indicate severe protein-energy malnutrition. A value less than 100 mg/dL may be considered a reliable index of severe protein-energy malnutrition.
Does transferrin bind ferritin?
Most of the transferrin-bound iron is used for the synthesis of hemoglobin by developing erythroid cells. Such a binding inhibits translation of ferritin mRNA and stabilizes the mRNA for transferrin receptors.
Why is transferrin high in Ida?
High transferrin signifies low iron, which means there is less iron bound to transferrin, allowing for a high circulation of non-bound iron transferrin in the body, revealing a possible iron deficiency anemia.
Does ferritin bind to transferrin?
Iron in the labile pool that exceeds requirement for the synthesis of functional heme and nonheme iron-containing proteins is stored within the iron-storage protein, ferritin. Such a binding inhibits translation of ferritin mRNA and stabilizes the mRNA for transferrin receptors.
What does high soluble transferrin receptor mean?
The level of soluble transferrin receptor (sTfR) will be increased with iron deficiency. If you have anemia and your sTfR level is elevated, then it is likely that you have iron deficiency anemia.