What are the side effects of moclobemide?
Moclobemide side effects
- Fast or racing heartbeat.
- pounding or irregular heartbeat.
- neck stiffness.
- severe throbbing headache which starts at the back of the head and radiates forward.
- slow heartbeat.
Does moclobemide increase serotonin?
Since moclobemide increases the concentrations of serotonin and noradrenaline in the brain, it can have significant interactions with both selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), even in therapeutic doses.
Does moclobemide cause Cheese reaction?
Unlike irreversible MAO-inhibitors, moclobemide has a negligible propensity to induce hypertensive crisis after ingestion of tyramine-rich food (“cheese-reaction”). Therefore, dietary restrictions are not as strict.
How does moclobemide work in the brain?
Moclobemide works by interfering with brain chemicals, called neurotransmitters. It works by reducing the action of an enzyme called monoamine oxidase A. By doing this, it increases the levels of the neurotransmitters, serotonin, dopamine and noradrenaline.
What type of drug is moclobemide?
Moclobemide is a monoamine oxidase (MAO) inhibitor used to treat certain types of mental depression. It works by blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system.
Is moclobemide safe?
Moclobemide is considered to be less toxic in overdose compared to older antidepressants, such as the tricyclic antidepressants and the irreversible and non-selective MAOIs, making it a safer antidepressant in the elderly or people with physical disorders.
Does moclobemide help anxiety?
Moclobemide has been found to be effective for the treatment of social anxiety disorder in both short and long-term placebo controlled clinical trials. Moclobemide is effective but not as effective as the irreversible MAOIs in the treatment of social phobia.
Does moclobemide increase dopamine?
Similar to other MAO-A inhibitors, moclobemide induces an increase in the rat brain levels of 5-hydroxytryptamine, norepinephrine and dopamine and a concomitant decrease of their deaminated metabolites.
What class of drug is moclobemide?
Moclobemide belongs to a group of medicines called antidepressants. Antidepressants are used to treat depression and work on the central nervous system. They are thought to work by their action on brain chemicals called amines, which are involved in controlling mood.
What is moclobemide used for?
What is moclobemide used to treat?
What is moclobemide tablets for?
Moclobemide is indicated for the treatment of major depressive episodes. Adults: Initial usual dose 300 mg, administered in divided doses after meals. The tablets are for oral administration and should be taken with fluid.
What are the side effects of stopping moclobemide?
Stop taking moclobemide and get emergency help immediately if any of the following effects occur: 1 Fast or racing heartbeat 2 pounding or irregular heartbeat 3 neck stiffness 4 severe throbbing headache which starts at the back of the head and radiates forward 5 slow heartbeat
Are there side effects to taking amitriptyline and moclobemide?
In a multicenter comparison of moclobemide, amitriptyline, and placebo, gastrointestinal discomfort, headache, and dizziness occurred in over 20% of moclobemide-treated patients; insomnia was also common [ 11 ]. In healthy volunteers there were no effects of moclobemide on psychomotor performance.
Why is moclobemide underprescribed in the United States?
Reversible selective MAOIs such as moclobemide are widely underprescribed due to the misconception that the side effect profiles are analogous to that of the irreversible and non-selective MAOIs.
Is there any evidence of liver toxicity with moclobemide?
Unlike the irreversible MAOIs there is no evidence of liver toxicity with moclobemide. Moclobemide has a similar efficacy profile compared to other antidepressants but is significantly superior to the tricyclic antidepressants and the classic (unselective or irreversible) MAOIs, in terms of tolerance and safety profile.