What does positive for PAX8 mean?
PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).
How is ovarian clear cell carcinoma treated?
The standard surgical treatment of patients with EOC is based on hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy with peritoneal sampling and lymphadenectomy, and cytoreductive surgery is added especially for advanced cases.
What is the rarest malignant ovarian tumor?
An extremely rare form of ovarian cancer is called small cell carcinoma of the ovary, or SCCO. Most of the women who get it are young. It tends to be fast-growing. Although it’s not technically an ovarian cancer, primary peritoneal carcinoma (PPC) is very closely related.
What does PAX8 negative mean?
PAX8 is considered a negative marker for mesothelioma. This means mesothelioma cancer cells usually do not test positive for PAX8. PAX8 is a common marker for kidney cancer, thyroid cancer and cancers of the female reproductive system.
What is PAX8 gene?
The PAX8 gene belongs to a family of genes that play critical roles in the formation of tissues and organs during embryonic development. The PAX gene family is also important for maintaining the normal function of certain cells after birth.
Is clear cell carcinoma fatal?
Patients with clear cell renal cell carcinoma (CCRCC) tend to have a worse prognosis than patients with other histologic subtypes of RCC, with 5-year disease-specific survival rates of 50-69%, compared with 67-87% for papillary RCC and 78-87% for chRCC.
What is the most common ovarian malignancy?
Epithelial ovarian cancer, which arises from the surface of the ovary (the epithelium), is the most common ovarian cancer. Fallopian Tube Cancer and Primary Peritoneal Cancer are also included within this designation. Germ Cell ovarian cancer arises from the reproductive cells of the ovaries, and is rare.
Who are PAX8 competitors?
Top 10 Pax8 Alternatives & Competitors
- Switchfast Technologies.
- Alta Vista Technology.
- Accenture.
- Magna5.
- Navisite Services.
- Code Zero.
- ATG Consulting.
- OneNeck IT Solutions.
Where is the PAX8 gene located?
The PAX8 gene is located on chromosome 2 and is a member of the paired box (PAX) family of transcription factors. The gene encodes for a nuclear protein, which contains a paired box domain, an octapeptide, and a paired-type homeodomain.
How are PAX8 and WT1 used in cancer research?
A total of 124 cases of ovarian carcinomas (84 serous papillary, 18 endometrioid, 12 mucinous, 10 clear cell) and 243 cases of invasive breast carcinomas (178 ductal, 65 lobular) were immunostained with Pax8 and WT1 by tissue microarrays to see the differential expression.
Where can I find the pathology outline PAX8?
PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainspax8.html. Accessed September 12th, 2021. Nuclear marker with expression in epithelial neoplasms of thyroid, thymic, ovarian, endometrial, endocervical, fallopian tube and renal origin
Are there cases of PAX8 and WT1 negative?
In 4 cases (6%), stains were negative for both markers. In the 52 cases of metastatic serous carcinoma, PAX8 was detected in 44 cases (85%) and WT1 in 48 cases (92%); 2 cases showed immunoreactivity only for PAX8, and 6 cases showed immunoreactivity only for WT1.
Which is a useful marker for ovarian carcinoma?
Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas The ovary is a common site of involvement for metastasis and the breast is one of the most common sources. Metastatic breast carcinoma can mimic a primary ovarian carcinoma.