Does eslicarbazepine cause hyponatremia?
Hyponatremia is an important side effect of some AEDs, especially oxcarbazepine and carbamazepine [57, 58]. Eslicarbazepine seems to have a lower incidence of hyponatremia than these drugs, occurring in only 0.6–1.5% of patients [42, 59, 60].
What is the difference between eslicarbazepine and carbamazepine?
The main distinction between eslicarbazepine acetate and carbamazepine is the lack of a toxic epoxide. Eslicarbazepine acetate is currently being developed as adjunctive treatment for partial onset seizures, with the aim of improving the efficacy and tolerability profiles of oxcarbazepine and carbamazepine.
Does Aptiom cause low sodium?
A: APTIOM may cause the level of sodium in your blood to be low. Symptoms of low-blood sodium include: nausea. irritability.
How is Aptiom metabolized?
Aptiom is rapidly and extensively metabolized to its major active metabolite by hydrolytic first-pass metabolism. Its elimination is primarily renal. Age, gender, and race do not affect the pharmacokinetics of Aptiom. Treatment with Aptiom should be initiated at a dosage of 400 mg once daily.
How does eslicarbazepine acetate work?
Eslicarbazepine acetate is broken down by the body into the eslicarbazepine, which is the form that helps to prevent seizures. During a seizure, electrical activity in the brain may be too fast in some areas. Eslicarbazepine works to slow down this electrical activity to prevent or stop seizures.
What is eslicarbazepine good for?
Eslicarbazepine is used alone or together with other medicines to control partial seizures (convulsions) in the treatment of epilepsy. Eslicarbazepine belongs to a class of medicines called anticonvulsants. It acts in the brain to prevent seizures.
What is eslicarbazepine used for?
Eslicarbazepine is used in combination with other medications to control focal (partial) seizures (seizures that involve only one part of the brain). Eslicarbazepine is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.
Is zebinix good for seizures?
Zebinix was effective, although slightly less than carbamazepine, at reducing seizures after 6 months of treatment: 71% of patients who took Zebinix and did not prematurely withdraw from the study (276 out of 388 patients) were seizure-free after 6 months compared with 76% of patients taking carbamazepine (300 out of …
What is the side effects of eslicarbazepine?
Headache, shaking, drowsiness, tiredness, dizziness, unsteadiness, feeling of spinning, nausea, or vomiting may occur.
Which is better oxcarbazepine or ESL for hyponatremia?
Both oxcarbazepine- and eslicarbazepine acetate-induced hyponatremia occurred particularly in elderly epilepsy patients. Recent evidence suggests that eslicarbazepine acetate (ESL) might be an appropriate alternative to carbamazepine (CBZ) and oxcarbazepine (OXC) due to its better safety profile.
Are there any antiepileptic drugs that cause hyponatremia?
2 b Center of Epilepsy , Beijing Institute for Brain Disorders , Beijing , China. Hyponatremia induced by antiepileptic drugs (AEDs) has not received sufficient attention in patients with epilepsy. Areas covered: We reviewed articles between 1966 and 2015 about hyponatremia as an adverse effect of AEDs in patients with epilepsy.
How is the diagnosis of hyponatremia made?
Diagnostically, the initial step is to differentiate hypotonic from nonhypotonic hyponatremia. Hypotonic hyponatremia is further differentiated on the basis of urine osmolality, urine sodium level, and volume status.
Is there a link between AEDs and hyponatremia?
Areas covered: We reviewed articles between 1966 and 2015 about hyponatremia as an adverse effect of AEDs in patients with epilepsy. The incidence, clinical symptoms, onset times of AEDs-induced hyponatremia are discussed in detail, as are the risk factors associated with AEDs-induced hyponatremia and mechanisms underlying its development.