How do you reconstitute hydrocortisone injections?
Hydrocortisone should be reconstituted by adding not more than 2ml of sterile Water for injections to the contents of one vial. A homogeneous solution will be obtained by shaking gently.
How do you administer hydrocortisone IV?
Systemic therapy in adults: 100 to 500mg hydrocortisone (1 to 5ml) administered by slow intravenous injection, taking at least half to one minute. This dose can be repeated three or four times in 24 hours, depending upon the condition being treated and the patient’s response.
What is the molecular weight of hydrocortisone?
362.46 g/mol
Hydrocortisone/Molar mass
What is Hemisuccinate used for?
Methylprednisolone hemisuccinate is a water soluble corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and …
What are side effects of hydrocortisone?
The most common side effects of hydrocortisone tablets are feeling dizzy, headaches, swollen ankles and feeling weak or tired. Taking hydrocortisone tablets can affect your immune system so you’re more likely to get infections.
How do you make hydrocortisone solution?
Dissolve 40 mg hydrocortisone in 10 ml 95% ethanol (non-denatured) and filter sterilize using 0.2 µm pore nylon syringe filter. Store at -70°C or below. 2. To make 1000X working stock, dilute 1:10 in sterile calcium and magnesium-free D- PBS.
Can hydrocortisone be given subcutaneously?
Conclusions: S.c. administration of 100 mg hydrocortisone shows excellent pharmacokinetics for emergency use with only a short delay in cortisol increase compared with i.m. injection. It has a good safety profile and is preferred by patients over i.m. injection.
Where do you inject hydrocortisone?
Hydrocortisone injection may be administered into a large muscle such as the buttock or hip, into a vein, or added to the intravenous (IV) fluid bag. Dosing varies and is based on the condition being treated.
Is hydrocortisone PO and IV equivalent?
What is the equivalent dose of oral prednisolone to intravenous (IV) hydrocortisone? Prednisolone 5mg orally is equivalent to hydrocortisone 20mg intravenously (equivalent anti-inflammatory dose).
How is hydrocortisone metabolised?
Metabolism: Metabolized in the liver to inactive glucuronide and sulfate metabolites. Excretion: Inactive metabolites and small amounts of unmetabolized drug are excreted by the kidneys. Insignificant quantities of drug are excreted in feces. Biological half-life of hydrocortisone is 8 to 12 hours.