What are the side effects of mitotane?
Common side effects may include:
- nausea, vomiting, loss of appetite;
- diarrhea;
- drowsiness;
- depressed mood, weakness, lack of energy;
- dizziness, spinning sensation; or.
- mild skin rash.
Is mitotane a chemotherapy?
The most commonly recommended chemotherapy drug for adrenal cancer is mitotane. In addition to destroying adrenal cancer cells, mitotane suppresses the adrenal gland’s production of hormones.
How much does mitotane cost?
Mitotane is a generic prescription medicine used to treat cancer of the adrenal gland that cannot be treated by surgery. It comes in the form of an oral tablet and can only be purchased through a prescription. The brand-name version of this drug is Lysodren. The average retail price of Mitotane is about $121.99.
How is mitotane administered?
Recommended Dose The recommended initial dose of LYSODREN is 2 g to 6 g orally, in three or four divided doses per day. Increase doses incrementally to achieve a blood concentration of 14 to 20 mg/L, or as tolerated. LYSODREN is a cytotoxic drug. Follow applicable special handling and disposal procedures.
Does mitotane cause neutropenia?
Blood and lymphatic system disorders: All blood cells can be affected with mitotane treatment. Leucopenia (including neutropenia), anemia and thrombocytopenia have been reported frequently during mitotane treatment (see section 4.8).
How is mitotane excreted?
Excretion. No unchanged mitotane is found in urine or bile. Approximately 10% of the administered dose is recovered in the urine as a water-soluble metabolite. A variable amount of metabolite (1%-17%) is excreted in the bile.
Why do dogs with Cushing’s pant?
The basis for increased panting in dog’s with Cushing’s disease is multifactorial. First, Cushing’s disease results in increased fat deposits in the abdominal cavity and around the chest. Second, an increase in liver size impedes the diaphragm from being able to expand with ease.
How do you take mitotane?
Mitotane pills are taken twice or three times a day. Swallow the pills whole with a glass of water during or after a meal consisting of fatty foods. You will usually take a low dose of mitotane. The dose will then be gradually increased.
How is mitotane used to treat adrenal cancer?
Mitotane is used to treat cancer of the adrenal glands. It works by slowing the growth of or killing adrenal gland cells and also decreases the amount of hormones made by the adrenal gland. How to use Mitotane Tablet Take this medication by mouth with or without food as directed by your doctor, usually 3 or 4 times daily.
What should I do if I miss a dose of mitotane?
Lab and/or medical tests (such as cortisol levels, liver function, mitotane blood levels) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose.
How does mitotane affect the central nervous system?
Concurrent use /of central nervous system depression producing medications with mitotane/ may produce additive central nervous system depressant effects. Mitotane may inhibit the adrenal response to corticotropin; this may interfere with the therapeutic response to corticotropin.
Can you get a rash from taking mitotane?
Mitotane can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash.