What is SPP1 gene?
SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Pediatric Systemic Lupus Erythematosus and Urolithiasis. Among its related pathways are Integrin cell surface interactions and Development_Hedgehog and PTH signaling pathways in bone and cartilage development.
Is osteopontin a glycoprotein?
Osteopontin (OPN) is a phosphorylated acidic glycoprotein that functions as an immune modulator, and affects wound healing [166].
What type of protein is osteopontin?
Osteopontin is an extracellular structural protein and therefore an organic component of bone. Synonyms for this protein include sialoprotein I and 44K BPP (bone phosphoprotein). The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.
What does osteopontin do in bone?
OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts.
What is osteopontin and osteocalcin?
Osteocalcin (OC) and osteopontin (OPN) are major non-collagenous proteins (NCPs) involved in bone matrix organization and deposition. In spite of this, it is currently unknown whether OC and OPN alter bone morphology and consequently affect bone fracture resistance.
What cell secretes osteopontin and osteocalcin?
Mature osteoblasts
4.5 Mature osteoblasts. The mature osteoblasts secrete collagen and proteins into the bone matrix, including several growth factors. Osteocalcin and osteopontin are expressed in these mature cells, as well as OPG, a decoy receptor for RANK-L that will block osteoclast formation [16].
Is osteopontin secreted?
OPN is a secreted phosphorylated glycoprotein that mediates diverse biological functions. Originally isolated from bone, OPN was later shown to have a wider distribution (Brown et al. 1992).
Which of the following stimulates osteoclast activity?
Parathyroid hormone stimulates osteoclast activity, meaning the answer is d).
What does bone Sialoprotein do?
BSP (MW 34 kDa) is a major non-collagenous protein in mineralizing connective tissues, such as dentin, cementum, bone, and calcified cartilage tissues. BSP is involved in regulating hydroxyapatite crystal formation in bones and teeth (Fisher et al., 2001).
What are the function of osteoclast?
Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/ monocyte lineage that circulate in the blood after their formation in the bone marrow.
What is an osteoclast cell?
Osteoclasts are multinucleated cells that derive from hematopoietic progenitors in the bone marrow which also give rise to monocytes in peripheral blood, and to the various types of tissue macrophages. Osteoclasts are formed by the fusion of precursor cells.
Where is Osteonectin found?
High levels of immunodetectable osteonectin are found in active osteoblasts and marrow progenitor cells, odontoblasts, periodontal ligament and gingival cells, and some chondrocytes and hypertrophic chondrocytes. Osteonectin is also detectable in osteoid, bone matrix proper, and dentin.
What are the diseases associated with the SPP1 gene?
GeneCards Summary for SPP1 Gene SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Pediatric Systemic Lupus Erythematosus and Urolithiasis. Among its related pathways are ERK Signaling and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway.
How is FSTL1 related to proteolytic activation of SPP1?
FSTL1 directly bound to the proform of SPP1/osteopontin, restraining proteolytic activation of SPP1, which led to inactivation of integrin/CD44-associated signaling. Serum osteopontin (and biglycan) concentrations have a positive correlation with liver fibrosis in patients with chronic hepatitis B.
How is SPP1 overexpression related to overall survival?
SPP1 overexpression is related to worse overall survival in patients with lower-grade gliomas. OPN may fit within the Goldilocks paradigm with respect to cardiovascular disease. Acute increases are protective, attenuate vascular calcification, and promote postischemic neovascularization.
How does SPP1 affect second generation EGFR TKI resistance?
Our results suggest that SPP1 enhanced the second-generation EGFR TKI resistance in lung cancer, and inhibiting SPP1 might be a therapeutic target to overcome afatinib resistance. levels of OPN affected the number of T cells in obesity and antibodies against cleaved OPN antagonize OPN-T cell interactions.