What is Villonodular synovitis?
Pigmented villonodular synovitis (PVNS) is a condition that causes the synovium—the thin layer of tissue that lines the joints and tendons—to thicken and overgrow. The mass or tumor that results from this overgrowth is not cancerous and does not spread (metastasize) to other areas of the body.
Is pigmented villonodular synovitis an autoimmune disease?
Pigmented villonodular synovitis is a rare disease of unknown etiology mostly affecting the knee and foot. Until now an association with autoimmune diseases has not been reported.
Is pigmented villonodular synovitis cancerous?
Pigmented villonodular synovitis (PVNS) is a type of benign (non-cancerous) tumor that arises from the soft connective tissue of joints. Any joint can be affected, although the tumor is most commonly found in the knee or hip joint. Although it can be painful, PVNS usually does not spread.
What is the incidence of pigmented villonodular synovitis?
PVNS is an uncommon disease. Prevalence is approximately 9.2 cases of extra-articular and 1.8 cases of intra-articular disease per 1 million population. Localized lesions are more common than diffuse involvement, comprising 77% of total lesions in one review, with a 3.3:1 localized-to-diffuse predominance ratio.
Can PVNS become malignant?
Malignant PVNS is an extremely rare condition but established concept involving a malignant form of GCTTS or PVNS. Enzinger and Weiss proposed the definition of the condition as a malignant lesion occurring with concomitant or previously documented conventional PVNS at the same site [1].
Is PVNS serious?
PVNS has been described as a growth or a tumor in the lining of the joint. While it is accurately labeled as a tumor, it is not cancer and it is not typically life-threatening.
What does PVNS feel like?
If you have PVNS, you’ll notice swelling and stiffness in a joint, most often your knee. The joint may hurt. You may have a “popping” feeling when you move the joint. The symptoms usually appear gradually and may come and go over time.
Can synovial lining grow back?
Synovium can grow back and may require repeat surgery.
Can synovitis be caused by trauma?
Causes of Synovitis Synovitis is linked to several other health issues within the joints. It can also be caused by trauma. Some of the most common causes of synovitis include: Overuse or overworking of a joint with a repetitive motion.
Is pigmented villonodular synovitis genetic?
There have been studies suggesting that PVNS could be caused by specific genetic changes in the cells lining the joint. More studies are needed to research this association.
What is pigmented villonodular synovitis ( PVNS )?
Pigmented villonodular synovitis (PVNS) is a rare proliferative process that affects the synovial joints, tendon sheaths, and bursas. In 1852, Chassaignac1reported the first case of a lesion in the flexor tendon sheath of the second and third fingers; this was subsequently reported in other joints.
Which is the most common site of villonodular synovitis?
Pigmented villonodular synovitis is a rare proliferative condition of the synovium. Although the condition can present in any joint, the knee is the most commonly affected site. Despite being a benign condition, pigmented villonodular synovitis is often aggressive, with marked extra-articular extension in some cases.
Is there a cure for pigmented villonodular synovitis?
The cause of PVNS is unknown. Treatment involves surgery to remove the tumor and damaged portions of the synovium. [1] [2] [3] This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed.
What are the symptoms of diffuse villonodular synovitis?
Localized PVNS causes pain and swelling in the affected joint. The swelling can be quite dramatic. Other symptoms may include locking, catching, and instability in the joint. In diffuse PVNS, there is often a gradual onset of symptoms including joint pain, swelling, and stiffness. In both types, the symptoms may come and go over time.