What does CD103 do?

What does CD103 do?

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name.

What are CD11c cells?

CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4.

Do macrophages express CD103?

Dendritic cells (DCs) and macrophages (Mfs) inte- grate microbial signals and direct adaptive immunity. LP MNPs consist of conventional dendritic cells (DCs), most of which express the integrin CD103, and CX3CR1+ intestinal mac- rophages (Mfs) (Bogunovic et al., 2012; Farache et al., 2013).

What is the function of integrins?

Integrins regulate cellular growth, proliferation, migration, signaling, and cytokine activation and release and thereby play important roles in cell proliferation and migration, apoptosis, tissue repair, as well as in all processes critical to inflammation, infection, and angiogenesis.

What is the function of CD11c?

CD11c has been proposed to function in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T cell proliferation by Langerhans cells. Using assays to quantify CD11c-mediated cell adhesion, we demonstrate that CD11c recognizes ICAM-2 and VCAM-1.

What is CD14 a marker for?

Cluster of differentiation 14 (CD14) was described as monocyte/ macrophage differentiation antigen on the surface of myeloid lineage, such as monocytes, macrophages and dendritic cells (DCs). It has been commonly used in normal tissue or blood and in leukemia as a marker for myeloid cells.

What is CD206?

CD206, a mannose receptor, is mainly expressed on the surface of alternatively activated macrophages where it acts as a pattern recognition receptor and plays a role in innate and adaptive immunity.

Do dendritic cells express cd20?

Plasmacytoid dendritic cells (pDCs) are known mainly for their secretion of type I IFN upon viral encounter. These CD2hiCD5+CD81+ cells express classical pDC markers, as well as the toll-like receptors that enable conventional pDCs to respond to viral infection.

What are the two functions of integrins?

Integrins also function as signal transducers, activating various intracellular signaling pathways when activated by matrix binding. Integrins and conventional signaling receptors often cooperate to promote cell growth, cell survival, and cell proliferation.

What is a primary function of integrins quizlet?

Integrins. What is the primary function of integrins (heterophilic)? They integrate the outside of the cell (ECM) with the inside.

What does CD11c bind to?

CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1.

Is CD14 a PRR?

CD14, one of the first identified PRRs, plays multiple roles in microbial recognition and signaling.