Are chondrocytes and osteoblasts the same?
The vertebrate skeleton is known to be formed by mesenchymal cells condensing into tissue elements (patterning phase) followed by their differentiation into cartilage (chondrocytes) or bone (osteoblasts) cells within the condensations.
Do chondrocytes become osteocytes?
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation.
What is the main difference between an osteoblast and Osteocyte?
The key difference between osteoblasts and osteocytes is that osteoblasts are a type of bone cells responsible for the formation of new bones while osteocytes are a type of bone cells that maintain the bone mass. Bone is a living and growing tissue that makes the skeleton of humans and other vertebrates.
What is a chondrocyte cell?
Chondrocytes are metabolically active cells that synthesize and turnover a large volume of extra cellular matrix (ECM) components such as collagen, glycoproteins, proteoglycans, and hyaluronan [2]. Chondrocytes are derived from MSCs and occupy only 1%–5% of the total cartilage tissue [7].
Is chondrocyte a cartilage cell?
Chondrocytes are the cells responsible for cartilage formation, and they are crucial for the process of endochondral ossification, which is useful for bone development. Also, by mimicking skeletal development chondrocytes play a critical role in fracture repair.
Does a chondrocyte have a nucleus?
Note the numerous chondrocytes in this image, each located within lacunae and surrounded by the cartilage they have produced. These cells have relatively small nuclei and often demonstrate lipid droplets in their cytoplasm.
What causes chondrocyte proliferation?
Androgen stimulates chondrocyte proliferation and matrix production, and thereby contributes to the increased long bone growth during the pubertal growth spurt. Estrogen affects growth plate cartilage through systemic as well as direct effects.
What is chondrocyte hypertrophy?
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy.
How can you tell the difference between an osteoblast and an osteoclast?
The main difference between osteoblast and osteoclast is that osteoblast is involved in the formation and mineralization of bones whereas osteoclast is involved in the breakdown and resorption of bones. The osteogenic cells in bones are developed into osteoblasts.
What is the Canaliculus?
Medical Definition of canaliculus : a minute canal in a bodily structure: as. a : one of the hairlike channels ramifying a haversian system in bone and linking the lacunae with one another and with the haversian canal.
What organelles are in a chondrocyte?
Chondrocytes’ size and shape vary depending on the anatomical layer, but all of them has organelles like endoplasmic retinaculum and Golgi membrane for matrix synthesis. Cytoskeleton of chondrocytes is composed of actin, tubulin and vimentin filaments.
What is chondrocyte proliferation?
During this process, a cartilage template is formed in which chondrocytes proliferate and differentiate into hypertrophic chondrocytes and are gradually replaced by bone. The coordinated proliferation and differentiation of chondrocytes ensures the continuous elongation of the epiphyseal growth plates.
What’s the difference between chondroblasts and chondrocytes?
Chondroblasts are a type of immature cells whereas chondrocytes are a type of mature cells. The main difference between chondrocytes and chondroblasts is that chondroblasts secrete the extracellular matrix of the cartilage whereas chondrocytes are involved in the maintenance of the cartilage.
Which of these is the correct definition of osteocytes?
An osteocyte is a type of cell that makes up bone. These cells are derived from osteoblasts , which are bone-forming cells. In general, they make up the majority of the mass of adult bone tissue in humans. Each cell within the bone tissue is typically connected to others, which work together to help create a strong matrix…
Are chondrocytes located in lacunae?
Chondrocytes, or chondrocytes in lacunae, are cells found in cartilage connective tissue. They are the only cells located in cartilage, they produce and maintain the cartilage matrix, which is a type of lake in which the chondrocytes swim.
Does matrix of the bone contain osteocytes?
Osteocyte, a cell that lies within the substance of fully formed bone. It occupies a small chamber called a lacuna, which is contained in the calcified matrix of bone . Osteocytes derive from osteoblasts, or bone-forming cells, and are essentially osteoblasts surrounded by the products they secreted.