What is maprotiline used for?
Maprotiline is used to treat depression, bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods), and anxiety. Maprotiline is in a class of medications called tetracyclic antidepressants.
Is maprotiline still available?
Mylan discontinued maprotiline tablets in June 2021.
Is maprotiline a sedating?
Maprotiline causes a strong initial sedation (first 2 to 3 weeks of therapy) and is therefore indicated to treat agitated patients or those with suicidal risks. It causes anticholinergic side effects (dry mouth, constipation, confusion, tachycardia) with a lower incidence than amitriptyline.
What is fluoxetine HCL good for?
Fluoxetine is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It is often used to treat depression, and also sometimes obsessive compulsive disorder and bulimia. Fluoxetine helps many people recover from depression, and it has fewer unwanted effects than older antidepressants.
Does maprotiline cause weight gain?
In conclusion, the results indicate that treatment of lean patients with depressive disorder with maprotiline results in an increase in serum ghrelin and reduction in adiponectin levels. Weight gain due to maprotiline treatment may be related to its negative effects on the metabolic variables.
Does Maprotiline have side effects?
Drowsiness, dizziness or lightheadedness; confusion; vision problems; dryness of mouth; constipation; and difficulty in urinating may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of maprotiline.
Is doxepin an SSRI?
Pharmacology. Doxepin is a tricyclic antidepressant (TCA). It acts as a serotonin–norepinephrine reuptake inhibitor (SNRI) (a reuptake inhibitor of serotonin and norepinephrine), with additional antiadrenergic, antihistamine, antiserotonergic, and anticholinergic activities.
How is maprotiline different from other cyclic antidepressants?
Maprotiline shares many of the actions of the tricyclic antidepressants although unlike tricyclic antidepressants, maprotiline does not inhibit the reuptake of serotonin, except at much higher (500-fold) concentrations.
Does fluoxetine make you sleep?
Serotonin reuptake inhibitors (SSRIs) like escitalopram (Lexapro), citalopram (Celexa), paroxetine (Paxil), and fluoxetine (Prozac), taken for depression or anxiety, can make you feel sleepy.
What is the best time of day to take fluoxetine?
For example, the manufacturer of Prozac (fluoxetine) recommends it be taken in the morning because it can make some people feel more energized, especially at the beginning of treatment.
Is it safe to take maprotiline hydrochloride tablets?
Maprotiline hydrochloride tablets are contraindicated in patients hypersensitive to Maprotiline and in patients with known or suspected seizure disorders. It should not be given concomitantly with monoamine oxidase (MAO) inhibitors.
What is the chemical formula for maprotiline hydrochloride?
Maprotiline hydrochloride, USP is a tetracyclic antidepressant, available as 25 mg, 50 mg and 75 mg tablets for oral administration. Its chemical name is N-methyl-9,10-ethanoanthracene-9 (10H)-propylamine hydrochloride, and its structural formula is: Maprotiline hydrochloride is a fine, white to off-white, practically odorless crystalline powder.
How is maprotiline used in the treatment of depression?
Maprotiline is an antidepressant. Maprotiline affects chemicals in the brain that may be unbalanced in people with depressive disorders. Maprotiline is used to treat major depressive disorder, depressive neurosis, manic depressive illness, or anxiety related to depression.
How does maprotiline hydrochloride affect the central nervous system?
Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors. Maprotiline hydrochloride is a member of anthracenes.