What is the chemical structure of fosfomycin?

What is the chemical structure of fosfomycin?

Fosfomycin tromethamine

PubChem CID	10199068
Structure	Find Similar Structures
Chemical Safety	Laboratory Chemical Safety Summary (LCSS) Datasheet
Molecular Formula	C7H18NO7P
Synonyms	FOSFOMYCIN TROMETHAMINE 78964-85-9 C7H18NO7P FOSFOMYCINTROMETAMOL Monurol (TN) More…

What type of drug is fosfomycin?

Fosfomycin is a novel class of antibacterial drugs. Technically, “antibiotic” refers only to antimicrobials derived from bacteria or molds but is often (including… read more with a chemical structure unrelated to other known antibiotics.

Is fosfomycin a penicillin?

Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by Streptomyces fradiae.

Is fosfomycin an aminoglycoside?

Fosfomycin is a phosphonic acid antibiotic active against gram-positive and gram-negative. Tobramycin is an aminoglycoside with gram-negative activity….Fosfomycin/tobramycin.

Combination of
Fosfomycin	Phosphonic acid
Tobramycin	Aminoglycoside
Clinical data
Routes of administration	Inhalation

Is fosfomycin broad spectrum?

Fosfomycin is a bactericidal antibiotic that interferes with cell wall synthesis in both Gram-positive and Gram-negative bacteria by inhibiting the initial step involving phosphoenolpyruvate synthetase. It has a broad spectrum of activity against a wide range of Gram-positive and Gram-negative bacteria.

How is fosfomycin produced?

In general, FosA and FosX enzymes are produced by Gram-negative bacteria, whereas FosB is produced by Gram-positive bacteria. FosC uses ATP and adds a phosphate group to fosfomycin, thus altering its properties and making the drug ineffective.

What is gentamicin?

Gentamicin injection is used to treat serious bacterial infections in many different parts of the body. Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.

Is fosfomycin a strong antibiotic?

Is fosfomycin a strong antibiotic? Antibiotic resistance is extremely common among Enterobacteriaceae uropathogens. Fosfomycin was the most effective antibiotic.

Is fosfomycin a macrolide?

Despite its name (ending in -omycin) Fosfomycin is not a macrolide, but a member of a novel class of phosphonic antibiotics. Fosfomycin is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA.

Is fosfomycin bacteriostatic?

Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.

Does fosfomycin cover Serratia?

Fosfomycin shows very good activity against many gram-negative bacteria, such as E. coli, Proteus species, Klebsiella pneumoniae, Enterobacter species, Serratia marcescens, and Salmonella typhi.

What is ciprofloxacin used for?

About ciprofloxacin It belongs to a group of antibiotics called fluoroquinolones. It is used to treat serious infections, or infections when other anitbiotics have not worked. It’s used to treat bacterial infections, such as: chest infections (including pneumonia)

How is fosfomycin an epoxide and a phosphonic acid?

Fosfomycin is a phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus. It has a role as an antimicrobial agent and an EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor. It is an epoxide and a member of phosphonic acids. It derives from a phosphonic acid.

Where was the discovery of fosfomycin found?

Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels.

What is the mechanism of action of fosfomycin?

Mechanism of Action. Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall.

Are there any side effects to the drug fosfomycin?

FosC uses ATP and adds a phosphate group to fosfomycin, thus altering its properties and making the drug ineffective. The drug is well tolerated and has a low incidence of harmful side effects. Despite its name (ending in -omycin) Fosfomycin is not a macrolide.