What is bupivacaine hydrochloride used for?
Bupivacaine injection is used to numb an area of your body during or after surgery or other procedures, childbirth, or dental work. This medicine is also used to numb your shoulder after surgery for up to 72 hours.
What is bupivacaine made of?
Each mL contains bupivacaine hydrochloride and 0.0091 mg epinephrine bitartrate, with 0.5 mg sodium metabisulfite, 0.001 mL monothioglycerol, and 2 mg ascorbic acid as antioxidants, 0.0017 mL 60% sodium lactate buffer, and 0.1 mg edetate calcium disodium as stabilizer.
Is bupivacaine water soluble?
Bupivacaine hydrochloride is (±) -1-Butyl-2´,6´-pipecoloxylidide monohydrochloride, monohydrate, a white crystalline powder that is freely soluble in 95 percent ethanol, soluble in water, and slightly soluble in chloroform or acetone.
What type of drug is bupivacaine?
Bupivacaine is a prescription medication used as a local anesthetic (numbing medicine). Bupivacaine blocks the nerve impulses that send pain signals to your brain. Bupivacaine is available under the following different brand names: Marcaine and Sensorcaine.
What is Sensorcaine used for?
Sensorcaine (bupivacaine HCl) Injections is an anesthetic (numbing medicine) used as a local (in one area) anesthetic for a spinal block. Sensorcaine is available in generic form.
Is bupivacaine same as lidocaine?
Are Xylocaine and Marcaine the Same Thing? Xylocaine (lidocaine) and Marcaine (bupivacaine hydrochloride)are local anesthetics (numbing medicines used in one area). Marcaine is longer acting and used for a spinal block. Lidocaine is used for local or regional anesthesia.
Why bupivacaine is heavy?
Bupivacaine Heavy is hyperbaric and its initial spread in the intrathecal space is affected by gravity. Due to the small dose, the intrathecal spread results in a relatively low concentration, and the duration of local anaesthesia tends to be relatively shorter.
Why Bupivacaine is heavy?
Can Bupivacaine be given IV?
IV bupivacaine can quickly lead to cardiotoxicity. A Black Box warning for bupivacaine notes that the drug can cause profound disturbances in cardiac rhythm and contractility that are resistant to typical resuscitation efforts, making these mix-ups particularly deadly.
Is bupivacaine stronger than lidocaine?
Bupivacaine is considered to have a therapeutic ratio of 2:0 while lignocaine in combination with adrenaline has a therapeutic ratio of 2:3. Lignocaine is considered less toxic than bupivacaine. However, it has shown that the injection route alters the relative toxicity of local anesthetics.
Which last longer bupivacaine or lidocaine?
Results: When the time of anesthesia onset was analyzed according to both anesthetic solutions, the difference was in favor of lidocaine (p = 0.01). The duration of action was longer in the bupivacaine group than in the lidocaine group (p = 0.00002).
Which is the monohydrate form of bupivacaine hydrochloride?
Bupivacaine hydrochloride (anhydrous) is a racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic. It has a role as an adrenergic antagonist, an amphiphile, an EC 3.1.1.8 (cholinesterase) inhibitor,…
Which is the hydrochloride salt of ropivacaine?
Ropivacaine Hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
What does bupivicaine do to the neuronal membrane?
Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.