What is meant by functional genomics?
Functional genomics is the study of how genes and intergenic regions of the genome contribute to different biological processes. Functional genomics focuses on the dynamic expression of gene products in a specific context, for example, at a specific developmental stage or during a disease.
What is functional genomics example?
The earliest examples of functional genomics came in the form of “forward genetic” screens in model organisms such as bacteriophages, bacteria, budding yeast, fruit flies, and roundworms.
What is the aim of functional genomics?
The goal of functional genomics is to provide a comprehensive, annotated map of the downstream effects of all coding and non-coding parts of the genome.
What is plant genomics?
Plant genomics aims to sequence, characterize, and study the genetic compositions, structures, organizations, functions, and interactions/networks of an entire plant genome.
What are the methods used in functional genomics?
Different techniques that are widely used to understand the gene/protein function include RNA interference (RNAi), mutagenesis, mass spectrometry, genome annotation, and so on.
What is structural and functional genomics?
Structural genomics involves the physical nature of genomes and includes the sequencing and mapping of genomes. Functional genomics involves studying the expression and function of the genome. Genomics can also involve the investigation of interactions between genes and between genes and the environment.
How does functional genomics differ from comparative genomics?
For instance, comparative genomics involves comparing the genomes of different organisms. Functional genomics involves studying the expression and function of the genome. Genomics can also involve the investigation of interactions between genes and between genes and the environment.
Which database is used for functional genomics?
Functional genomics data are predominantly stored in one of two public databases: ArrayExpress at EMBL-EBI (Figure 4) GEO at NCBI.
What is plant genome organization?
The plant genome is organized into chromosomes that provide the structure for the genetic linkage groups and allow faithful replication, transcription and transmission of the hereditary information.
What does a plant genome consist of?
Plant nuclear genomes. The plant nuclear genome, consisting of the DNA and associated proteins, is organized into discrete chromosomes. Each unreplicated chromosome and metaphase chromatid consists of a single DNA molecule that is linear and unbroken from one end to the other (Figure 1).
What are the different types of plant viral vectors?
Table 1
| Virus vector | GE platform | Plant species |
|---|---|---|
| CaLCuV | CRISPR | Nicotiana benthamiana |
| WDV | CRISPR | Triticum aestivum |
| WDV | CRISPR | Oryza sativa |
| TRV | ZFN | Nicotiana tabacum and Petunia hybrida |
What is the difference between Structural & Functional Genomics?
What do you need to know about functional genomics?
Functional Genomics. Functional genomics is a branch that integrates molecular biology and cell biology studies, and deals with the whole structure, function and regulation of a gene in contrast to the gene-by-gene approach of classical molecular biology technique. From: Encyclopedia of Bioinformatics and Computational Biology, 2019.
How are phenotypes screened for in functional genomics?
This is done by either deletion or disruption of function (such as by insertional mutagenesis) and the resulting organisms are screened for phenotypes that provide clues to the function of the disrupted gene*
How is functional genomics used in chimpanzees?
Functional genomics studies of acute hepatitis B virus (HBV) infection in the chimpanzees has led to unique insights into how this virus evades the immune response and causes injury (Wieland et al., 2004).
Which is an example of functional genomics in bees?
For example, Toth et al. (2014) used a functional genomics approach to investigate whether genes involved in the expression of reproductively dominant (queen) or subordinate (worker) phenotypes are similar across social insect species that establish and maintain dominance with physical aggression ( Polistes wasps) or chemical signals (honey bees).