What is coagulation factor IX?
Coagulation factor IX is a man-made protein similar to a natural protein in the body that helps the blood to clot. Coagulation factor IX is used to treat or prevent bleeding in people with hemophilia B. This medication is not for treating people with hemophilia A factor VIII deficiency.
What is human factor IX?
Human Factor IX (Christmas factor) is a single-chain plasma glycoprotein (mol wt 57,000) that participates in the middle phase of the intrinsic pathway of blood coagulation.
What factor activates IX?
The coagulation protease factor IX is activated during hemostasis by the factor VIIa/tissue factor complex and by factor XIa.
What does a low factor 9 mean?
May also be called: Factor IX Deficiency. Hemophilia is a disease that prevents blood from clotting properly. A clot helps stop bleeding after a cut or injury. In hemophilia B (factor IX deficiency), the body doesn’t make enough factor IX (factor 9), one of the substances the body needs to form a clot.
Is factor IX a protein?
Factor IX is a protein produced naturally in the body. It helps the blood form clots to stop bleeding. Injections of factor IX are used to treat hemophilia B, which is sometimes called Christmas disease.
What is Factor 9 called?
Introduction. Hemophilia B is the second most common type of hemophilia. 1,2. It is also known as factor IX deficiency, or Christmas disease. It was originally named “Christmas disease” after the first person diagnosed with the disorder back in 1952.
What is factor IX called?
Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.
What type of protein is factor IX?
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
How is Factor 9 deficiency Treated?
Standard treatment is infusion of factor IX concentrates to replace the defective clotting factor. The amount infused depends upon the severity of bleeding, the site of the bleeding, and the size of the patient.
What causes factor IX deficiency?
What is factor IX used for?
FACTOR IX (fak tir nine) is used in patients with hemophilia B to help control bleeding. Some products may also be used to control bleeding in patients with other disorders that prevent the blood from clotting properly.
How to calculate the dose of alphanine mononine?
Individualize dosing based on severity of factor IX deficiency, extent and location of bleeding, and clinical status of patient AlphaNine SD, Mononine: 1 unit/kg x body wt (kg) x desired increase (% of normal) = Number of factor IX units required Injection site pain (6.2%) Altered taste sense (4.6%)
How is factor IX deficiency treated in humans?
Role in disease. Factor IX deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell vectors. Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding.
When to decrease the administration rate of factor IX?
Rate of administration should be individualized according to the specific product used and patient’s response If headache, flushing, or changes in pulse rate or blood pressure occur during administration of factor IX complex (human), decrease administration rate
How is factor IX expression affected by age?
Factor IX is inhibited by antithrombin. Factor IX expression increases with age in humans and mice. In mouse models, mutations within the promoter region of factor IX have an age-dependent phenotype.