What is hyper-CVAD regimen?
An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD regimen includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.
How effective is hyper-CVAD?
Patients treated with the hyper-CVAD regimen (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and cytarabine) are reported to have up to a 92% complete remission (CR) rate and 38% 5-year overall survival (OS) rate in clinical trials.
How is hyper-CVAD administered?
Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.
How long is hyper-CVAD?
Each cycle of hyper-CVAD lasts 21 days. But if you have hyper-CVAD before a stem cell transplant, you usually only have 2 cycles of each schedule.
What chemo regimen is hyper-CVAD?
An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.
What is hyper Cytoxan?
Detailed Description: The hyper-CVAD regimen is a combination of chemotherapy drugs including cyclophosphamide, vincristine, Adriamycin, and dexamethasone given together to for one “course” of treatment. This alternates with a course or combination of the chemotherapy drugs methotrexate and cytarabine.
What is pomp maintenance?
POMP (6-Mercaptopurine + Vincristine + Methotrexate + Prednisone) is a Treatment Regimen for Acute Lymphoid Leukemia (ALL)
What does Hyper CVAD stand for?
The term ‘hyper’ refers to the hyperfractionated nature of the chemotherapy, which is given in smaller doses, more frequently, to minimize side effects. ‘CVAD’ is the acronym of the drugs used in course A: cyclophosphamide, vincristine, doxorubicin (also known by its trade name, Adriamycin), and dexamethasone.
What is BFM protocol?
A modified version of the standard Berlin-Frankfurt-Munich (BFM) protocol for pediatric ALL was developed to achieve balance between toxicity and favorable response rates. Modification included a dose reduction of asparaginase and methotrexate during the consolidation and reinduction phase.
What chemo regimen is hyper CVAD?
What is hyper-CVAD Part B?
Each of the medications in HyperCVAD (Part B) (methotrexate + cytarabine) are designed to kill cancer cells in the blood stream and bone marrow. Goals of therapy: To eliminate leukemia cells from the body and to decrease symptoms from ALL, such as bleeding, bruising, and recurrent infections.
What does Hyper-CVAD stand for?
How is hyper CVAD used to treat cancer?
Acute lymphoblastic leukemia (certain types). Non-Hodgkin lymphoma (certain types). Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.
How to optimize use of the HyperCVAD regimen?
Learn more. Optimal administration of the hyperCVAD regimen requires awareness of its appropriate administration and supportive care practices. Practical management of anticipated toxicities and treatment of special patient populations with this regimen is reviewed.
Can you take vincristine during HyperCVAD maintenance phase?
Any dose reductions or omissions made during the intensive hyperCVAD phase should be continued during maintenance as well. In cases of liver dysfunction and total bilirubin >2 mg/dL, vincristine must be omitted.
What should I know about alternating HyperCVAD with cytarabine?
Alternating with hyperCVAD courses is high-dose MTX and cytarabine. Ensuring adequate MTX clearance and appropriate cytarabine dosing is critical for these even treatment courses (courses 2, 4, 6, 8). MTX is administered continuously over 24 hours, followed by high-dose cytarabine (HDAC).