What is superficial siderosis?
Superficial siderosis (SS) of the central nervous system (CNS) is a chronic condition consisting of hemosiderin deposition in the subpial layers of the brain (and spinal cord) due to chronic or intermittent low-grade extravasation of blood into the subarachnoid space.
Is superficial Siderosis fatal?
The symptoms and signs of SS are progressive and fatal. Exploration of potential sites responsible for intrathecal bleeding and subsequent hemosiderin deposition may prevent disease progression.
How is superficial Siderosis treated?
Treatment of SS involves identification and surgical correction of the bleeding source. Deferiprone, which is a lipid-soluble iron chelator that can penetrate the blood-brain barrier, is reportedly effective at improving the clinical symptoms and deposition of hemosiderin. It is thus a hopeful treatment option for SS.
How common is superficial Siderosis?
Superficial siderosis of the central nervous system is a rare condition caused by hemosiderin deposits in the subpial layers of the brain and spinal cord.
What does siderosis mean?
Medical Definition of siderosis 1 : pneumoconiosis occurring in iron workers from inhalation of particles of iron. 2 : deposit of iron pigment in a bodily tissue.
Is there a cure for superficial Siderosis?
There is currently no cure for Superficial Siderosis. The only medications currently available to treat SS are oral chelation drugs, which can cross the blood-brain barrier. The best known of these medications is deferiprone (Ferriprox). Oral chelation therapy carries risks and may not be advisable for all patients.
How long can you live with superficial siderosis?
Severe medical condition with expected life expectancy <3. years.
How is Siderosis treated?
What are the symptoms of superficial thrombophlebitis?
Superficial thrombophlebitis is an inflammation of a vein just below the surface of the skin, which results from a blood clot. This condition may occur after recently using an IV line, or after trauma to the vein. Some symptoms can include pain and tenderness along the vein and hardening and feeling cord-like.
What is the diagnosis and treatment of superficial siderosis?
[Diagnosis and treatment of superficial siderosis] Superficial siderosis (SS) is a rare condition in which hemosiderin is deposited on the pial surface of the brain and/or spinal cord. Hemosiderin deposition is the consequence of recurrent or persistent hemorrhage in the subarachnoid space. There are two types of SS.
What causes hemosiderin deposition on the pial surface?
Superficial siderosis (SS) is a rare condition in which hemosiderin is deposited on the pial surface of the brain and/or spinal cord. Hemosiderin deposition is the consequence of recurrent or persistent hemorrhage in the subarachnoid space.
How long does it take for thrombophlebitis to subside?
Symptoms generally subside in 1 to 2 weeks, but hardness of the vein may remain for much longer. Shown here is erythema following the vascular pattern on a lower extremity.