How do you infuse Cerezyme?
Cerezyme is administered by intravenous infusion over 1-2 hours. Dosage should be individualized to each patient. Initial dosages range from 2.5 U/kg 3 times a week to 60 U/kg q 2 weeks. 60 U/kg q 2 weeks is the dosage for which the most data are available.
What does Cerezyme do?
Cerezyme is an ERT (enzyme replacement therapy) designed to reduce the accumulation of a fatty substance called GL-1 in the spleen, liver, and bones. The build-up of GL-1 ultimately causes the signs and symptoms of Gaucher disease.
What is Cerezyme made of?
Cerezyme® is produced by recombinant DNA technology using mammalian cell culture (Chinese hamster ovary). Purified imiglucerase is a monomeric glycoprotein of 497 amino acids, containing 4 N-linked glycosylation sites (Mr = 60,430).
How do you administer vpriv?
Geriatric Use Among 205 patients who switched from imiglucerase to VPRIV, 52 patients were 65 years of age or older of which 10 were 75 years and older. The adverse reaction profile in elderly patients was consistent with that previously observed across pediatric and adult patients.
Who manufactures Cerezyme?
Cerezyme is a freeze-dried medicine containing imiglucerase, manufactured by Genzyme Corporation. It is given intravenously after reconstitution as a treatment for Type 1 and Type 3 Gaucher’s disease.
Where is Cerezyme manufactured?
Genzyme Corporation (Cambridge, MA) has begun shipping vials of newly produced Cerezyme (imiglucerase for injection) manufactured at its plant in Allston Landing, MA.
When was Cerezyme FDA?
1994: The FDA approves Cerezyme® (imiglucerase), an ERT drug Genzyme developed as a successor to Ceredase.
Is VPRIV a biologic?
VPRIV is indicated for long-term enzyme replacement therapy (ERT) for patients with type 1 Gaucher disease. VPRIV is indicated for long-term enzyme replacement therapy (ERT) for patients with type 1 Gaucher disease….Number of versions: 17.
| Published Date (What is this?) | Version | Files |
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| Nov 25, 2020 | 21 | download |
What is VPRIV used for?
VPRIV® (velaglucerase alfa for injection) is a form of enzyme replacement therapy (ERT) that’s used for long-term treatment of pediatric and adult patients with Type 1 Gaucher disease — a gene mutation that causes a lack of glucocerebrosidase.
How often should you take imiglucerase for Cerezyme injection?
Cerezyme® (imiglucerase for injection) is administered by intravenous infusion over 1-2 hours. Dosage should be individualized to each patient. Initial dosages range from 2.5 U/kg of body weight 3 times a week to 60 U/kg once every 2 weeks. 60 U/kg every 2 weeks is the dosage for which the most data are available.
When to use imiglucerase as an enzyme replacement therapy?
Indication & Usage. Cerezyme® (imiglucerase for injection) is indicated for long-term enzyme replacement therapy for pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions: anemia (low red blood cell count)
What are the side effects of Cerezyme infusions?
Each of the following events occurred in less than 2% of the total patient population. Reported side effects include nausea, abdominal pain, vomiting, diarrhea, rash, fatigue, headache, fever, dizziness, chills, backache, and rapid heart rate. Because Cerezyme therapy is administered by intravenous infusion,…
When to use Cerezyme for enzyme replacement therapy?
Cerezyme is right for you. Cerezyme ® (imiglucerase for injection) is indicated for long-term enzyme replacement therapy for pediatric and adult patients with a confirmed diagnosis of Type 1 Gaucher disease that results in one or more of the following conditions: Newly diagnosed?