What is doxorubicin soluble?
Doxorubicin hydrochloride is readily soluble in water, slightly soluble in normal saline, and sparingly soluble in alcohol. After reconstitution the solution is orange-red at neutral pH and is stable for 1 month at 5° C.
What are the properties of doxorubicin?
Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II.
Is doxorubicin water soluble?
Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Directions for Use: Doxorubicin is supplied as a lyophilized powder.
What is another name for doxorubicin?
Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®. In some cases health care professionals may use the trade names Adriamycin® or Rubex® when referring to the generic drug name Doxorubicin.
How do you dissolve doxorubicin?
For maximum solubility in aqueous buffers, doxorubicin (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Doxorubicin (hydrochloride) has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method.
How do you dilute doxorubicin?
Lyophilized powder: Reconstitute with NS, Sterile Water for Injection, or D5W to give a final concentration of 2 mg/mL. It is recommended that doxorubicin be slowly administered into the tubing of a freely running intravenous infusion of Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP.
How do you dissolve doxorubicin hydrochloride?
Why is doxorubicin called Red Death?
Additionally, some people may develop PPE, characterized by skin eruptions on the palms of the hand or soles of the feet, swelling, pain, and erythema. Due to these side effects and its red color, doxorubicin has earned the nickname “red devil” or “red death.”
What does AC mean in chemotherapy?
What is AC chemotherapy? AC is a combination of two chemotherapy drugs used to treat breast cancer. It takes its name from the initials of these drugs: doxorubicin (also known as Adriamycin) cyclophosphamide.
What is doxorubicin for?
Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells …
Can you freeze doxorubicin?
Doxorubicin hydrochloride, when reconstituted with sterile water for injection, may be refrigerated for six months or frozen for one month without loss of potency.
Is anthracycline an antibiotic?
A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die.
What kind of solubility does doxorubicin have in water?
Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.
What kind of color does doxorubicin hydrochloride look like?
Doxorubicin hydrochloride is an anthracycline. Adriamycin hydrochloride appears as orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9. (NTP, 1992)
What is the molecular formula for doxorubicin in DMSO?
Molecular Formula: C27H29NO11•HCl Molecular Weight: 579.98 g/mol Solubility:Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Purity: >99%
How is doxorubicin classified as an anthracycline?
The chemical classification of doxorubicin is Anthracyclines. Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin.