What kind of birth defects did Bendectin cause?

What kind of birth defects did Bendectin cause?

Butler also cited a two-month-old federally funded study indicating that women in early pregnancy who swallowed the original Bendectin tablets may have quadrupled the risk of pyloric stenosis, a birth defect of the stomach that restricts an infant’s ability to eat.

Why was Bendectin taken off the market?

“Bendectin” (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations.

What were the side effects of Bendectin?

Bendectin

• Dicycloverine.
• Doxylamine.
• Cohort Effect.
• Histamine Antagonist.
• Nausea and Vomiting.
• Nausea.
• Pyridoxine.
• Teratogenicity.

Is Bendectin a thalidomide?

These drugs were differentially marketed worldwide. As dis- cussed later, DES was primarily an American tragedy, thalidomide was a northern European and United Kingdom tragedy, and Bendectin/ Debendox was marketed to American, European, and United Kingdom populations.

What drug is in Unisom?

Doxylamine is an antihistamine, used to relieve symptoms of allergy, hay fever, and the common cold. This medication works by blocking certain natural substances (histamine, acetylcholine) that your body makes. This effect helps to relieve allergy/cold symptoms such as watery eyes, runny nose, and sneezing.

Is Bendectin the same as Diclegis?

Diclegis, approved by the FDA in 2013, is the rebranded version of an earlier medication called Bendectin. That pill was widely prescribed for more than 50 years, but in the late 1970s, lawsuits began calling into doubt its safety, alleging that the drug caused birth defects.

Who made Bendectin?

Bendectin was developed in the mid-1950s by the Wm. S. Merrell Company of Cincinnati, Ohio, from pharmaceutical ingredients that had been individually marketed for many years. It was indicated specifically for nausea and vomiting of pregnancy.

What is a DES daughter?

DES daughters: Women whose mothers took DES while pregnant with them. This exposed them to DES while they were growing in the womb. DES sons: Men whose mothers took DES while pregnant with them.

What are the ingredients in bendectin?

In its original formulation, Bendectin contained three ingredients: doxylamine succinate (an antihistamine), pyridoxine hydrochloride (vitamin B6) and dicyclomine hydrochloride (an antispasmodic). It became a leading treatment for NVP in the U.S., Canada, as well as internationally under different brand names.

Who made bendectin?

Can Unisom cause birth defects?

Doxylamine (Unisom): Cleft lip and cleft palate, pyloric stenosis, hypoplastic left heart syndrome, spina bifida, and neural tube defects.