What are Th1 diseases?
Th1 cells are involved in the pathogenesis of organ-specific autoimmune disorders, Crohn’s disease, Helicobacter pylori-induced peptic ulcer, acute kidney allograft rejection, and unexplained recurrent abortions.
What is Th1 dominance?
Th1 and Th2 cells are known to antagonize each other in a variety of ways [18, 19], and several chronic inflammatory autoimmune diseases such as multiple sclerosis (MS), diabetes and rheumatoid arthritis (RA) have been described as Th1 dominant diseases [20], while atopy and allergy are Th2 dominant diseases [21].
Is vitiligo Th1 or Th2 dominant?
The deficiency of TSLP gene expression produces the dominance of the Th1 immune response, which is involved in vitiligo development. IFN-γ is the most important cytokine, that is associated with the Th1 immune response (10).
What is the function of Th1?
The main effector functions of Th1 cells are in cell-mediated immunity and inflammation, including the activation of cytolytic and other effector functions of other immune cells such as macrophages, B cells, and CD8+ cytotoxic T lymphocytes (CTLs).
What are Th1 and Th2?
Th1 and Th2 cells play an important role in immunity. Th1 cells stimulate cellular immune response, participate in the inhibition of macrophage activation and stimulate B cells to produce IgM, IgG1. Th2 stimulates humoral immune response, promotes B cell proliferation and induces antibody production (IL-4).
Which is Th1 dominant or Th2 dominant in autoimmune disorders?
Put another way, autoimmune conditions generally have either a T cell upregulation and B cell suppression (Th1 dominant) or the opposite (Th2 dominant). It’s imperative that people with autoimmune disorders maintain Th1/Th2 balance.
Is the Th1 / Th2 system beneficial during pregnancy?
However, sometimes an imbalance of the Th1/Th2 system can be beneficial. For example, during pregnancy women have a tendency to shift towards a Th2 dominance, which is advantageous since a Th1 shift would induce rejection of the fetus.
What does Th2 stand for in the immune system?
The secondary B cell antibody response is called a “Th2 response”. In a healthy body, there is balance between the Th1 (T cell) and Th2 (B cell) parts of our immune system. And that’s the desirable state. However, sometimes an imbalance of the Th1/Th2 system can be beneficial.
Can you have green tea if you have Th2 dominance disorder?
Green tea has a proven track record of benefits for the average person and, if you do not have an autoimmune condition, it seems wise to include green tea into your diet. However if you have a diagnosed autoimmune condition, especially a Th2 dominance disorder, green tea might not be for you.