Does Akt have a PH domain?
Akt is a 480 amino acid protein that contains an N-terminal PH (pleckstrin homology) domain followed by a catalytic (kinase) domain and culminates in a regulatory C-terminal disordered tail (C-tail) (Figure 1A).
What is the function of the PH domain?
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.
What does PH domain bind to?
One group of PH domains appears to bind both phosphoinositides (with little specificity) and Arf (ADP-ribosylation factor) family small G-proteins, and are targeted to the Golgi apparatus where both phosphoinositides and the relevant Arfs are both present. Here, the PH domains may function as coincidence detectors.
Does Pleckstrin have a PH domain?
Pleckstrin is one of the rare proteins to contains two PH domains. * Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family.
What is the PH domain of AKT?
Group 3 PH domain
AKT has a Group 3 PH domain. The crystal structure of the PH domain of AKT1 bound to the inositol head group of PtdIns(3,4,5)P3, that is, myo-inositol(1,3,4,5)P4, has been determined and the mode of binding elucidated (32).
How much is a .PH domain?
Domain Registration in Philippines – . PH Domains
| Domain | Annual Price | Annual Price |
|---|---|---|
| .ph | $ 63 | 63 |
| .com.ph | $ 63 | 63 |
| .net.ph | $ 63 | 63 |
| .org.ph | $ 63 | 63 |
What is .PH domain name?
ph is the Internet country code top-level domain (ccTLD) for the Philippines.
What is the role of phosphatidylinositol?
Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their principal role is instructional: they interact with proteins. In summary, phosphoinositides contribute to the selection of peripheral proteins for each membrane and regulate the activity of the integral proteins.
Why .ph domain is expensive?
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How much does it cost to buy a website address?
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What is an example of Adaptor protein that has SH2 domain?
Examples of such adaptors include Nck, Crk, and Shc, as well as Grb2, which forms a complex with Sos, a nucleotide exchange molecule for Ras, and the regulatory subunit p85, which forms a complex with the catalytic subunit p110 of phosphatidylinositol 3′-kinase (PI3-kinase).
Which is the second messenger of the Akt PH domain?
The Akt PH domain has a high affinity for second messenger PI (3,4,5)P 3, binding to it preferentially over other phosphoinositides. Thus PI3K activity is essential for translocation of Akt to the membrane.
Which is PH domain of tyrosine protein kinase BTK?
PH domain of tyrosine-protein kinase BTK. Pleckstrin homology domain (PH domain) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
What are the PH domains of pleckstrin protein?
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. Pleckstrin contains two PH domains. ARAP proteins contain five PH domains. Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family.
How does Akt regulate phosphorylation of a protein?
Akt regulates a wide range of proteins by phosphorylation. Akt target substrates contain a minimum consensus sequence R-X-R-X-X- [Ser/Thr]-Hyd, where Hyd is a hydrophobic amino acid, although other factors such as sub-cellular localisation and 3-dimensional structure are important.