What is glucuronidation metabolism?
Glucuronidation involves the metabolism of parent compound by UDP-glucuronosyltransferases (UGTs) into hydrophilic and negatively charged glucuronides that cannot exit the cell without the aid of efflux transporters.
What is glucuronidation pathway?
Glucuronidation is a major phase II pathway for transforming dietary toxins, drugs, carcinogens, and other environmental chemicals into less toxic substances. It is the most important pathway for the human body’s elimination of the most frequently prescribed drugs.
Is glucuronidation an oxidation reaction?
Although oxidation does occur, both glucuronidation and sulfation are more efficient. The very high rate of glucuronidation of galangin points toward potential interactions with other molecules being substrates for, in particular, UGT1A9.
Which of the following enzymes is involved in glucuronidation reaction?
3.1 Glucuronidation. Glucuronidation reactions are catalyzed by a family of enzymes called uridine diphosphate-glucuronosyltransferases (UGTs), which likely evolved in response to the need to excrete lipophilic compounds from the body.
Which of the following enzyme is involved in glucuronidation reaction?
What happens during Glucuronidation?
n. a metabolic process by which drugs or other substances are combined with glucuronic acid to form more water-soluble compounds, which are more readily excreted by the kidneys or in bile. Glucuronidation is the most prevalent of the Phase II reactions of drug metabolism.
How is glucuronidation a reaction of conjugation?
Glucuronidation is a major and very frequent reaction of conjugation. It involves the transfer to the substrate of a molecule of glucuronic acid from the cofactor uridine-5′-diphospho-α-D-glucuronic acid (UDPGA).
How are glycosidic bonds involved in glucuronidation?
These linkages involve glycosidic bonds. Glucuronidation consists of transfer of the glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by any of several types of UDP-glucuronosyltransferase .
Which is less toxic phase of glucuronidation?
Sometimes toxic substances are also less toxic after glucuronidation. The conjugation of xenobiotic molecules with hydrophilic molecular species such as glucuronic acid is known as phase II metabolism .
Where does glucuronidation take place in the body?
O-glucuronidation is a frequent metabolic reaction of xenobiotic phenols and alcohols, yielding polar metabolites excreted in urine and/or bile.