What is the chemical structure of paclitaxel?
Paclitaxel consist of taxane ring with a four-membered oxetane side ring at positions C4 and C5 and an active homochiral ester side chain at C13 that binds to microtubules in a guanosine triphosphate (GTP) independent manner to induce cytotoxicity activity.
What is the chemical structure of Taxol?
Taxol,
| PubChem CID | 4666 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C47H51NO14 |
| Synonyms | 33069-62-4 LSM-1400 AC1L1IOG Paclitaxel-[d5] TAXOL, More… |
How many carbons does Taxol contain?
There are a total of 11 chiral carbons in Taxol.
What is paclitaxel article?
Paclitaxel is a chemotherapeutic agent used as therapy for several types of cancer. It has a long list of both approved and off-label malignancies for which it is used as both a primary agent and in conjunction with other medications.
What type of compound is paclitaxel?
Paclitaxel is a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy.
Is paclitaxel a compound?
D., (right) discovered paclitaxel, a lifesaving compound from the bark of the Pacific yew tree.
How many Stereocenters are in taxol?
Naming Stereogenic Centers in Taxol The eleven chiral centers are labled in magenta. A 3-D model of this compound is shown to its right. The molecule can be moved by using the mouse and zoomed by the shift key.
How many rings of different sizes are in taxol?
Many people have studied the main skeleton of taxol. The taxol backbone consists of an eight membered ring , a six membered ring and a four membered ring . Attached to these rings are several functional groups including and OH group, two benzoyl groups, an acetyl group and an oxetane ring.
Is paclitaxel platinum based?
Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial….
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Ovarian Cancer Primary Peritoneal Cavity Cancer | Drug: carboplatin Drug: cisplatin Drug: paclitaxel | Phase 3 |
How many functional groups are in Taxol?
14 functional groups
Taxol, isolated from the bark of the Pacific Yew tree, Taxus brevifolia, is an anticancer drug, which was first studied in the successful treatment of ovarian cancer. In 1969, 1,200 kg of tree bark was processed to produce 10.0 g of pure taxol. The molecule contains 14 functional groups.
How many chiral centers are in paclitaxel?
11 chiral centers
Taxol contains 11 chiral centers and four rings which make it a promising target for the total synthesis.
How is paclitaxel used in the treatment of cancer?
(NCI04) Paclitaxel is an antineoplastic agent which acts by inhibitor of cellular mitosis and which currently plays a central role in the therapy of ovarian, breast, and lung cancer.
How many stereoisomers are there in paclitaxel?
The nomenclature for paclitaxel is structured on a tetracyclic 17-atom skeleton. There are a total of 11 stereocenters. The active stereoisomer is (−)-paclitaxel (shown here). Undisturbed Pacific yew bark contains paclitaxel and related chemicals.
What kind of IC50 does paclitaxel have?
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. MedChem Express Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.;
When did paclitaxel become available as a generic?
Annual sales peaked in 2000, reaching US$1.6 billion; paclitaxel is now available in generic form. In October 2007 it was approved by Drug controller General of India for the treatment of breast cancer and launched by collaboration with Biocon.